From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transformation/transcription domain-associated protein , also known as TRRAP , is a
protein that in humans is encoded by the TRRAP
gene .
[5]
[6] TRRAP belongs to the
phosphatidylinositol 3-kinase-related kinase protein family.
Function
TRRAP is an
adaptor protein , which is found in various multiprotein
chromatin complexes with
histone acetyltransferase activity (HAT), which in turn is responsible for
epigenetic
transcription activation. TRRAP has a central role in
MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. It is required for p53/
TP53 -,
E2F1 -, and
E2F4 -mediated transcription activation. It is also involved in transcription activation mediated by the
adenovirus E1A, a viral
oncoprotein that deregulates transcription of key genes.
[7]
TRRAP is also required for the
mitotic checkpoint and normal
cell cycle progression. The
MRN complex (composed of
MRE11 ,
RAD50 , and
NBS1 ) is involved in the detection and repair of DNA
double-strand breaks (DSBs). TRRAP associates with the MRN complex and when TRRAP is removed, the complex shows reduced cDNA end-joining activity. Hence, TRRAP may function as a link between DSB repair and chromatin remodeling.
[8]
[9]
Interactions
Transformation/transcription domain-associated protein has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000196367 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000045482 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b
c McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (August 1998).
"The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins" . Cell . 94 (3): 363–74.
doi :
10.1016/S0092-8674(00)81479-8 .
PMID
9708738 .
S2CID
17693834 .
^ Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (December 1998).
"The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily" . Mol. Cell . 2 (6): 869–75.
doi :
10.1016/S1097-2765(00)80301-9 .
PMID
9885574 .
^ Murr R, Vaissière T, Sawan C, Shukla V, Herceg Z (August 2007). "Orchestration of chromatin-based processes: mind the TRRAP". Oncogene . 26 (37): 5358–72.
doi :
10.1038/sj.onc.1210605 .
PMID
17694078 .
S2CID
22598445 .
^ Robert F, Hardy S, Nagy Z, Baldeyron C, Murr R, Déry U, Masson JY, Papadopoulo D, Herceg Z, Tora L (January 2006).
"The Transcriptional Histone Acetyltransferase Cofactor TRRAP Associates with the MRN Repair Complex and Plays a Role in DNA Double-Strand Break Repair" . Mol. Cell. Biol . 26 (2): 402–12.
doi :
10.1128/MCB.26.2.402-412.2006 .
PMC
1346889 .
PMID
16382133 .
^ Herceg Z, Wang ZQ (March 2005).
"Rendez-vous at mitosis: TRRAPed in the chromatin" . Cell Cycle . 4 (3): 383–7.
doi :
10.4161/cc.4.3.1546 .
PMID
15711126 .
^
a
b Park J, Wood MA, Cole MD (March 2002).
"BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation" . Mol. Cell. Biol . 22 (5): 1307–16.
doi :
10.1128/mcb.22.5.1307-1316.2002 .
PMC
134713 .
PMID
11839798 .
^
a
b Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (August 2001).
"The p400 complex is an essential E1A transformation target" . Cell . 106 (3): 297–307.
doi :
10.1016/s0092-8674(01)00450-0 .
PMID
11509179 .
S2CID
15634637 .
^
a
b McMahon SB, Wood MA, Cole MD (January 2000).
"The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc" . Mol. Cell. Biol . 20 (2): 556–62.
doi :
10.1128/mcb.20.2.556-562.2000 .
PMC
85131 .
PMID
10611234 .
^
a
b Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003).
"c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation" . J. Biol. Chem . 278 (22): 20405–12.
doi :
10.1074/jbc.M211795200 .
PMC
4031917 .
PMID
12660246 .
^
a
b Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001).
"Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo" . Mol. Cell. Biol . 21 (20): 6782–95.
doi :
10.1128/MCB.21.20.6782-6795.2001 .
PMC
99856 .
PMID
11564863 .
Further reading
Herceg Z, Wang ZQ (2006).
"Rendez-vous at mitosis: TRRAPed in the chromatin" . Cell Cycle . 4 (3): 383–7.
doi :
10.4161/cc.4.3.1546 .
PMID
15711126 .
Murr R, Vaissière T, Sawan C, Shukla V, Herceg Z (2007). "Orchestration of chromatin-based processes: mind the TRRAP". Oncogene . 26 (37): 5358–72.
doi :
10.1038/sj.onc.1210605 .
PMID
17694078 .
S2CID
22598445 .
McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (1998).
"The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins" . Cell . 94 (3): 363–74.
doi :
10.1016/S0092-8674(00)81479-8 .
PMID
9708738 .
S2CID
17693834 .
Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (1999).
"The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily" . Mol. Cell . 2 (6): 869–75.
doi :
10.1016/S1097-2765(00)80301-9 .
PMID
9885574 .
Brand M, Yamamoto K, Staub A, Tora L (1999).
"Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction" . J. Biol. Chem . 274 (26): 18285–9.
doi :
10.1074/jbc.274.26.18285 .
PMID
10373431 .
McMahon SB, Wood MA, Cole MD (2000).
"The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc" . Mol. Cell. Biol . 20 (2): 556–62.
doi :
10.1128/MCB.20.2.556-562.2000 .
PMC
85131 .
PMID
10611234 .
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y (2000).
"Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis" . Cell . 102 (4): 463–73.
doi :
10.1016/S0092-8674(00)00051-9 .
PMID
10966108 .
S2CID
18047169 .
Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (2001).
"UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation" . EMBO J . 20 (12): 3187–96.
doi :
10.1093/emboj/20.12.3187 .
PMC
150203 .
PMID
11406595 .
Lee YJ, Chung TS, Yoon YS, Lee MS, Han SH, Seong GJ, Ahn KJ (2001).
"The role of functional MR imaging in patients with ischemia in the visual cortex" . American Journal of Neuroradiology . 22 (6): 1043–9.
PMC
7974786 .
PMID
11415895 .
Lang SE, McMahon SB, Cole MD, Hearing P (2001).
"E2F transcriptional activation requires TRRAP and GCN5 cofactors" . J. Biol. Chem . 276 (35): 32627–34.
doi :
10.1074/jbc.M102067200 .
PMID
11418595 .
Park J, Kunjibettu S, McMahon SB, Cole MD (2001).
"The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis" . Genes Dev . 15 (13): 1619–24.
doi :
10.1101/gad.900101 .
PMC
312730 .
PMID
11445536 .
Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM (2001).
"The p400 complex is an essential E1A transformation target" . Cell . 106 (3): 297–307.
doi :
10.1016/S0092-8674(01)00450-0 .
PMID
11509179 .
S2CID
15634637 .
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (2001).
"Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo" . Mol. Cell. Biol . 21 (20): 6782–95.
doi :
10.1128/MCB.21.20.6782-6795.2001 .
PMC
99856 .
PMID
11564863 .
Park J, Wood MA, Cole MD (2002).
"BAF53 Forms Distinct Nuclear Complexes and Functions as a Critical c-Myc-Interacting Nuclear Cofactor for Oncogenic Transformation" . Mol. Cell. Biol . 22 (5): 1307–16.
doi :
10.1128/MCB.22.5.1307-1316.2002 .
PMC
134713 .
PMID
11839798 .
Yanagisawa J, Kitagawa H, Yanagida M, Wada O, Ogawa S, Nakagomi M, Oishi H, Yamamoto Y, Nagasawa H, McMahon SB, Cole MD, Tora L, Takahashi N, Kato S (2002).
"Nuclear receptor function requires a TFTC-type histone acetyl transferase complex" . Mol. Cell . 9 (3): 553–62.
doi :
10.1016/S1097-2765(02)00478-1 .
PMID
11931763 . (Retracted, see
doi :
10.1016/j.molcel.2014.04.017 ,
PMID
24932468 ,
Retraction Watch . If this is an intentional citation to a retracted paper, please replace {{
retracted |...}}
with {{
retracted |...|intentional=yes}}
. )
Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD (2002).
"TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins" . Mol. Cell. Biol . 22 (14): 5054–63.
doi :
10.1128/MCB.22.14.5054-5063.2002 .
PMC
139788 .
PMID
12077335 .
Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB (2002).
"Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes" . Mol. Cell. Biol . 22 (16): 5650–61.
doi :
10.1128/MCB.22.16.5650-5661.2002 .
PMC
133988 .
PMID
12138177 .
Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics . 3 (2): 217–23.
doi :
10.1002/pmic.200390030 .
PMID
12601814 .
S2CID
6035986 .
Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (2003).
"c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation" . J. Biol. Chem . 278 (22): 20405–12.
doi :
10.1074/jbc.M211795200 .
PMC
4031917 .
PMID
12660246 .