Young et al first demonstrated in 2002 that teeth could be regenerated from cells.[4]
The first clinical trial on tooth started in 2023 in Japan, for a medicine stimulating tooth regrowth by inhibition of
USAG-1.[5][6][7]
Challenges
The majority of stem cell studies have stopped at the stage of animal studies and have not proceeded to clinical trials due to numerous safety and
ethical concerns. The potential risks of undesired tissue formation,
tumourigenesis, and
metastasis has not yet been resolved.[8]
^Kellomäki, Minna; Törmälä, Pertti (2003). "Processing of Resorbable Poly-α-Hydroxy Acids for Use as Tissue-Engineering Scaffolds". Biopolymer Methods in Tissue Engineering. Vol. 238. pp. 1–10.
doi:
10.1385/1-59259-428-X:1.
ISBN978-1-59259-428-3.