Thrombospondin-3 (TSP3) is a
protein that in humans is encoded by the THBS3gene.[5][6]
The protein encoded by this gene belongs to the
thrombospondin family. Thrombospondin family members are adhesive
glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.[7] This protein forms a
pentameric molecule linked by a single
disulfide bond. This gene shares a common promoter with metaxin 1.[6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to
SARS-CoV-2 infection.[8]
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Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42.
doi:
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Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93.
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