Names | |
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Other names
2-thenoic acid; tenoic acid; Rhinotrophyl
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Identifiers | |
3D model (
JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.007.659 |
EC Number |
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KEGG | |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C5H4O2S | |
Molar mass | 128.15 g·mol−1 |
Appearance | white solid |
Melting point | 125–127 °C (257–261 °F; 398–400 K) |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Thiophene-2-carboxylic acid is an organic compound with the formula SC4H3CO2H. It is one of two mono carboxylic acids of thiophene, the other being thiophene-3-carboxylic acid. [1] Copper(I) thiophene-2-carboxylate is a catalyst for Ullmann coupling reactions.
It can be prepared by the oxidation of thiophene-2-carboxaldehyde or, more practically, 2-acetylthiophene. [2]
Upon treatment with LDA, thiophene-2-carboxylic acid undergoes double deprotonation to give the 5-lithio derivative, a precursor to many 5-substituted derivatives. [3]
Thiophene-2-carboxylic acid has been widely studied as a substrate in coupling reactions and olefinations. [4] [5]
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