Combination of | |
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Telmisartan | Angiotensin II receptor antagonist |
Amlodipine | Calcium channel blocker |
Clinical data | |
Trade names | Twynsta, others |
License data | |
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
KEGG |
Telmisartan/amlodipine, sold under the brand name Twynsta among others, is a fixed-dose combination medication used to treat high blood pressure. [2] It is a combination of telmisartan, an angiotensin II receptor antagonist, and amlodipine, as the besilate, a calcium channel blocker. [2] It is taken by mouth. [2]
Common side effects include dizziness, swelling, and back pain. [2] Severe side effects may include low blood pressure, kidney problems, electrolyte problems, and a heart attack. [2] Use during pregnancy may harm the baby. [2] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle. [2]
The combination was approved for medical use in the United States in 2009. [2] The combination is on the World Health Organization's List of Essential Medicines. [4] [5] It is available as a generic medication. [6]