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Some text in this article was taken from http://ghr.nlm.nih.gov/gene=wrn (public domain)

Someone should render PDBID 3AAF (RQC domain of WRN protein bound to DNA) rather than this rather uninformative structure that was uploaded by its own creator.

150.212.110.182 ( talk) 20:29, 15 March 2010 (UTC) reply

I think that it would be helpful to have a link to the WRN gene on the main page of Werner syndrome. — Preceding unsigned comment added by Iamwillthinnes ( talk • contribs) 15:28, 20 March 2014 (UTC) reply

Added link, thanks! RegOH ( talk) 00:43, 16 April 2014 (UTC) reply

I think that the opening paragraph, in which you describe a helicase and its function, may be better used as a first paragraph in the body of the article. Iamwillthinnes ( talk) 15:31, 20 March 2014 (UTC) reply

The second sentence of the first body paragraph has awkward wording, I think that it could be phrased better. Iamwillthinnes ( talk) 15:35, 20 March 2014 (UTC) reply

reworded, hopefully more clear now. RegOH ( talk) 00:43, 16 April 2014 (UTC) reply

• It might be helpful to expand the "interactions" section if possible-- How do the interactions take place? What are the effects of these interactions?

left "interactions" at the end as a list for readers to observe at a glance, but added more detailed information about more important interactions in "Structure and Function" section. RegOH ( talk) 00:46, 16 April 2014 (UTC) reply

• The formatting of the references at the end is odd--Is there a problem with the formatting that you can fix?

Akhan50699 ( talk) 03:33, 25 March 2014 (UTC) reply

I think the references look normal now, it's possible that there was an issue earlier with formatting that someone else fixed. RegOH ( talk) 00:46, 16 April 2014 (UTC) reply

Structure and Function

• The third sentence is awkward, consider revising it, moving it elsewhere, or removing it (it seems redundant considering the sentences following — perhaps combine it with the previous sentence?).
  • It was awkward. I removed it. Thanks. RegOH ( talk) 15:07, 10 May 2014 (UTC) reply

Clinical Significance

• Consider moving the sentence talking about the normal function of the Werner protein to the beginning of the paragraph. I think this would help people better understand the effects of mutations in this gene if they know what the normal function of the non-mutated protein is.
  • Thank you for the input. RegOH ( talk) 15:10, 10 May 2014 (UTC) reply

• You might want to consider adding links to areas like base-excision repair or nonhomologous end joining in the function section.
  • added the links, thanks. RegOH ( talk) 15:17, 10 May 2014 (UTC) reply

• I made some minor grammatical changes, and if any of the changes seem wrong to you, you can just change them back.
  • thank you. RegOH ( talk) 15:17, 10 May 2014 (UTC) reply

• It almost seems like the post-translational modifications section could fit under structure and function.
  • made post-translational modifications a subsection of structure and function. RegOH ( talk) 15:17, 10 May 2014 (UTC) reply

• I know other articles don't always do this, but if you want, you can expand the interactions section to include more specifics on each interaction. — Preceding unsigned comment added by Mjurgens369 ( talk • contribs) 22:51, 26 April 2014 (UTC) reply
  • Other articles about enzymes, genes, etc, have a similar interaction section. Leaving it as is for now. Thank you. RegOH ( talk) 15:17, 10 May 2014 (UTC) reply

• I think you may benefit from adding a few more wikilinks. Such as tetrameric, hexameric, catalytic. There may not be articles with those titles, but you can link it to something that explains it a little more.
• You can also change the class of your article to a C on the quality scale since you added more information. You would just have to go the the template on top and change to Class=C. Im sure you can do something to fill in the genetics template as well. Rraju2 ( talk) 16:49, 10 May 2014 (UTC) reply