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Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Theophylline.
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the corresponding article in German. (June 2014) Click [show] for important translation instructions.
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What amount of theophylline is there in a cup of black tea? Is there any in coffee?
Caffeine is metabolized in the liver into three primary metabolites: paraxanthine (84%), theobromine (12%), and theophylline (4%) Reference: # ^ Caffeine. The Pharmacogenetics and Pharmacogenomics Knowledge Base. Retrieved on 2006-08-14.
Q:If theophylline is naturally occuring in green tea, than how much is occuring in a cup? What are the effects for someone on medication to this combination?
Q: What are the effects of infusing theophylline and guarna into the same concentrate?
Recent research at Imperial College London under Prof Peter Barnes has demonstrated that low doses of theophylline raise the level of the enzyme HDAC2, which may then allow glucocorticoids to reduce lung inflamation, which they are not normally effective at with COPD patients. The doses used in the trials were much less than used when theophylline was once a commonly prescribed bronchodilator for COPD treatment.
"In chronic obstructive pulmonary disease (COPD) patients and asthmatic patients who smoke HDAC2 is markedly impaired as a result of oxidative and nitrative stress so that inflammation is resistant to the anti-inflammatory effects of corticosteroids." Barnes PJ, Eur J Pharmacol.2006 Mar 8;533(1-3):2-14. -- Onefishtwofish 12:20, 2 July 2006 (UTC)
From the article: 'Bioavailability is 100%. However, taking the drug late in the evening may slow the absorption process, without affecting the bioavailability. Taking the drug after a meal high in fat content will also slow down the absorption process, without affecting the bioavailability. There is one exception. Taking UniphylTM, a long-acting theophylline formulation, after a meal high in fat content will increase its bioavailability.'
I am completely ignorant of what bioavailability means, but I'm guessing that it isn't supposed to exceed 100%, making this a rather curious statement, since it implies > 100% bioavailability w/ the use of some product. --anonymous, 31 March, 2008 —Preceding unsigned comment added by 75.172.48.115 ( talk) 17:44, 31 March 2008 (UTC)
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How many references are needed to get the citations needed tag removed? To me the current number of references should do. T.vanschaik ( talk) 18:12, 22 February 2012 (UTC)
Current draft seems to unfairly compare
cocoa beans concentration by dry weight (mg/g) with
brewed tea concentration in volume (by liter) (i.e., diluted by water).
As a result, hot cocoa or other prepared foods containing cocoa diluted with water or other ingredients may be assumed to be better sources of theophylline than they are, and tea may be falsely assumed to be inferior by comparison, though it may not be.
Apples - to - apples comparison needed.
I have had acute extreme tachycardia and elevated BP twice from accumulated cocoa, presumably due to theophylline toxicity, and both times it was reversed starting in 10 minutes and completely in 2 hours with 50 mg orally chewed atenolol. In other words, as the reference in the article says, cardioselective beta blockers do work. Note that a drug such as atenolol of course won't address any CNS issues. -- IO Device ( talk) 18:11, 11 July 2015 (UTC)
Basic information to add to this article: the etymology of the word "theophylline." 173.88.246.138 ( talk) 14:58, 19 April 2021 (UTC)