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Currently, the major proteins that make up HIV are described briefly in the Structure section and then again in the subsections for individual genes. References to the proteins are linked to the genes that code for them. I think is confusing since it's not immediately apparent why clicking on "gp120" goes to "env" - and really, most of the information is about the proteins, not the genes. I suggest instead having subsections for each protein, and converting the list of genes into a simple bullet list that says things like "env: codes for the envelope proteins
gp120 and
gp41".
The "genetic variability" section is currently redundant between this article and
HIV. Either it should be removed from this article and replaced with a brief "see" link, or the section in the main article should be replaced with a summary and link.
←
Hob00:09, 1 November 2005 (UTC)reply
This should be under the main article, not here. Specific mutations in proteins could be discussed in this section though. --
Bob00:27, 1 November 2005 (UTC)reply
No two HIV genomes are the same, not even from the same person, causing some to speculate that HIV is a quasispecies of a virus.[1]
This was the second sentence of the article. I deleted it, since it does not correctly use the term quasispecies, and I don't have the time to correct it right now. "HIV" is NOT speculated to form a quasispecies, but rather, the many individual HIV virions or HIV populations within a given individual are sometimes refered to as quasispecies.
References
^WainHobson, S., 1989. HIV genome variability in vivo. AIDS 3: supp 1; 139.
Citation
Can someone change the 1983 on the first line of the main article to 1981; I am unsure how to do citations and someone keeps changing it back to 1983 when the first cases were recorded on June 5th 1981.
Here is evidence, and I am sure that you will find plenty more all over the net and in lots of books:
Actually 1983 is correct, 1981 was when the first cases of AIDS were noticed because of the opportunistic infections. The virus itself wasn't discovered until 1983. For the first few years no one knew what was causing it. Luc Montagnier and others in France
PMID6189183, and Robert Gallo and others published at the same time here
PMID6601823. The search for the cause is covered in
And the Band Played On. I'll reword the intro sentence to make this more clear. -
Optigan13 (
talk)
02:34, 21 May 2008 (UTC)reply
gp160
Does the sequence run gp120→gp41, or gp41→gp120? (Reading N to C, of course.) 02:17, 23 August 2008 (UTC)
links
I just changed a load of the intra-wiki links as they were direting to the wrong place. Apparently someone else edited at the same time and there was an edit cnflict? I dont know what that means though, the links are correct now anyway
Philman132 (
talk)
12:21, 18 May 2009 (UTC)reply
Genome length
"The RNA component is 9749 nucleotides long[5]".
This is too specific. The length of the genome varies considerably, particularly in Env which has a primary amino acid sequence ranging from approximately 840-860 residues. This equates to a 60 base discrepancy, and there are outliers which push this up further. If you want to get it right check out the los Alamos sequence database. —Preceding
unsigned comment added by David 08:54, 26 June 2010 (UTC)
Actually, i've just read a little further and this article is mainly untrue.
I'm happy to help out a later date.
David —Preceding
unsigned comment added by
Contributions/ ([[User talk:|talk]]) 08:58, 26 June 2010 (UTC)
Thanks for the reference, I assume you mean
here. I downloaded all the "2008" sequences and get the following stats:
Number of sequences: 1257
Smallest: 7995
Largest: 9868
Average length: 8995.1
Number of sequences: 7
Smallest: 9214
Largest: 9769
Average length: 9582.7
The
NCBI viral genome resource gives 9181 and 10359 for HIV1 and HIV2 respectively. I could see EMBL and NCBI being biased towards longer sequences and the LANL may include truncated and other non-functional sequences.
Something like "The RNA component is on average approximately 9kb nucleotides long[5-8]" -- or similar, adding references to these sources would unlikely to be reverted.--
Paul (
talk)
09:23, 27 June 2010 (UTC)reply
To consider for inclusion - atomic level structure simulation of capsid
Why isnt this in yet?!?!?!
I came to this article expecting this specifically to be focued on and so am quite surprised such a breakthrough (the EXACT, atom by atom) capsid structure model discovery not even mentioned! Why? — Preceding
unsigned comment added by
71.37.135.2 (
talk)
15:41, 6 June 2013 (UTC)reply
If I'm not mistaken, this primary research publication was in the most recent issue of Nature. Wikipedia emphasises secondary sources that help to place primary sources in proper context (see
WP:MEDRS). That said, there is probably a place for this finding in the article, and I would encourage you to be
bold and edit as you see fit. Cheers!
Keepcalmandcarryon (
talk)
15:56, 6 June 2013 (UTC)reply