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Regarding the proposed merger of
EP300 into
P300/CBP, as the the two proteins P300 and EP300 are identical, I support the merger. In addition, since the
P300/CBP page is essentially a superset of the of the information contained in the
EP300 page, I suggest that we replace the EP300 page with a redirect to P300/CBP.
Boghog220:42, 25 June 2007 (UTC)reply
I do not support the merger. I agree that P300 and EP300 are identical, but the
P300/CBP article deals with common features of two distinct proteins,
EP300 and
CREBBP (also called CBP). I'd suggest leaving all three articles, but put the majority of the gene-specific information on the individual gene pages.
AndrewGNF03:51, 9 October 2007 (UTC)reply
De-merging: As
AndrewGNF pointed out above, CPB (
CREBBP) and p300 (
EP300) are two related but distinct proteins each encoded by a different gene. Therefore a separate article for each is justified. In addition, there is frequent reference in the literature to the p300/CBP protein family which was the reason why this article was created. I have therefore restored and expanded the
CREBBP article and moved the CREBBP {{PBB}} template from this article back to the CREBBP article. This article which is about the protein family contains the more compact {{protein}} templates while the gene/protein specific articles contain the more complete {{PBB}} templates.
Renaming: The
p300-CBP Transcription Factors at the U.S. National Library of Medicine
Medical Subject Headings (MeSH) entry is somewhat inappropriately named since neither CBP nor p300 is a
transcription factor (neither directly bind to DNA and hence by definition are not transcription factors). These proteins are more properly classified as
coactivators. Therefore I have renamed this article as p300-CBP coactivator family to more accurately reflect the subject matter of this article.
Boghog2 (
talk)
11:45, 4 April 2009 (UTC)reply