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In the wikipedia autism article, I read that
and
I propose, therefore, that autism be added to the list under the "non-autoimmune" heading, to demonstrate that it at least being considered as a possible autoimmune disease. Objections? Piedmont ( talk) 11:19, 2 May 2021 (UTC)
My apologies for not focusing on this but I am about to spend some time, so if you are interested in this page, please post here and I will try to accommodate any comments and suggestions.
First, I would like to come up with a way to characterize these diseases better. Here are the issues:
1. We need a way to decide whether a disease is "officially" autoimmune. The Rose Bona criteria are published and the original list was part of the article on Autoimmune Disease - when the list was moved, the reference to Rose Bona was not. I will add it back as appropriate. However, the Rose Bona criteria, a modification of the Witebsky postulates (which I will also notate) are so stringent that only a handful of diseases qualify (autoimmune thyroiditis and myasthenia gravis are 2 I know of). The rest are implicated by the presence of antibodies (strong evidence of autoimmune etiology) or simply circumstantial evidence (no other etiology, predominantly affect women, follow a pattern of flare-ups and remissions). In many cases, it is a judgment call where a disease fits.
2. We need a way to characterize diseases that are caused by autoimmune processes only some of the time. A patient who has their pancreas removed due to cancer will suffer from type 1 diabetes, but not from an autoimmune process. In other cases, infections or genetics can cause disease in one individual that is caused by autoimmune processes in another. In genetics, we use the term "penetrance" to describe the rate at which people with the gene exhibit the phenotype we expect. In autoimmunity, we need a term to describe the percentage of persons suffering from a disease that have the disease due to an autoimmune process.
I would love feedback on both of these issues.
Also please advise on my Wikipedia etiquette, as I am still not well versed in it.
Second, as I had posted here earlier, I will be changing the table at least to remove the flags referring to the prior version of the table:
A "Accepted" in prior version of this table S "Suspected" in the prior version of this table N Not listed in prior version of this table Y Listed in the prior version of this table with "Accepted/Suspected" left blank
The prior version of the table is over 3 years old and if someone wants to see it they can go to the history.
I also propose to reuse "N" to indicate "New research" that changes the status of a condition. For example, Chronic Fatigue Syndrome has received some new credibility from the NIH. I propose that any disease that has a footnote pointing to research published in the past year that changes the "Level of Acceptance" should be flagged with an N and a footnote. I propose to adhere to a "no footnote, no N" rule. This will help ensure all changes are supported with references. I will review on a regular basis and remove "N" values that are a year or so old to keep the meaning accurate.
Aaron Abend (
talk)
12:37, 26 December 2019 (UTC)
2602:306:35FA:B090:F9B8:34:BF0A:72E2 ( talk) 03:57, 10 July 2017 (UTC) Interstitial Cystitis is listed as Kidney Disease. It is a Urinary Bladder Disease (as you'll see when you click its related link(s)). July 9, 2017 2602:306:35FA:B090:F9B8:34:BF0A:72E2 ( talk) 03:57, 10 July 2017 (UTC)
Thanks for the info - I will change that! Aaron Abend ( talk) 12:37, 26 December 2019 (UTC)
A further issue is the qualifiers list's "C" designation, "given to diseases that are classified by Rose and Bona as having 'circumstantial' evidence of autoimmune etiology. [These] are, therefore, actual autoimmune diseases."
Actual diseases, yes. Actually autoimmune, not necessarily, for the evidence of that is, per Messrs. Rose and Bona, merely circumstantial. Mucketymuck ( talk) 04:11, 3 October 2020 (UTC) 04:09, 3 October 2020 (UTC)
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(at least since the H1N1 flu vaccine triggered Narcolepsy phenomenon) Source: http://med.stanford.edu/narcolepsy.html May I change it? — Preceding unsigned comment added by 2605:A000:D020:C900:4990:F141:538A:DE59 ( talk) 14:16, 6 September 2017 (UTC)
"C A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. This designation is given to diseases that are classified by Rose Bona as having "circumstantial" evidence of autoimmune etiology. Diseases in this list with a "C" are, therefore, actual autoimmune diseases, rather than comorbid symptoms, which appear after this list."
So who is Rose Bona? Her name isn't a link to the article on her. A google search on her turned up nothing.
And isn't the Wikipedia rule that evidence must have been prior published in an authoritative journal, archive, book, or periodical. That is, Wikipedia isn't supposed to publish original research.
Anyways, so who is Rose Bona? Thanks.
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Hello everybody - Would a medical professional please add to this list and describe Autoimmune autonomic ganglionopathy (AAG)? I have added a link to its Wikipedia article under the "See also" section because I am not a medical professional and I am not qualified to write about this. You may help someone who has this rare disease. Thank you. Entertainment Buff 16:23, 10 January 2019 (UTC)
This edit changes the table entry for eczema to claim it is an autoimmune disease. The edit does not provide a citation. The page on eczema does not say it is or is not autoimmune. Either way, if it is autoimmune, it should not be in the table in the section Non-autoimmune. I am going to revert the linked edit. Kimen8 ( talk) 00:17, 15 October 2023 (UTC)
All paper cited were published before 2010, with the earliest dated back to 2001, over 20 years ago. More recent research, especially those that focuses on increased cases associated with the 2009 flu pandemic and the use of Pandemrix vaccine during this period, actually supports the idea that one form of the disease, narcolepsy type 1 (NT1, also known as narcolepsy with cataplexy), may be an autoimmune disorder. There is still no evidence showing that nacrolepsy type 2 (NT2, also know as narcolepsy without cataplexy) is an autoimmune disorder. Whether this can elevate the level of acceptance to "possible" is not what me as a non-professional can determine. Meanwhile, I will add an update inline template. Conflict of interest: I am an NT1 patient.
Here are some recent papers about the possibility of NT1 as autoimmune disorder (some are paywalled):
Giannoccaro, M. P. et al. (2021) ‘Reviewing the Clinical Implications of Treating Narcolepsy as an Autoimmune Disorder’, Nature and Science of Sleep, 13, pp. 557–577. doi: 10.2147/NSS.S275931.
Kornum, B.R. (2021) ‘Narcolepsy type I as an autoimmune disorder’, The Human Hypothalamus - Neuroendocrine Disorders, pp. 161–172. doi:10.1016/b978-0-12-820683-6.00012-9.
Liblau, R.S. et al. (2023) ‘The immunopathogenesis of narcolepsy type 1’, Nature Reviews Immunology, 24(1), pp. 33–48. doi:10.1038/s41577-023-00902-9. Kaileeslight ( talk) 07:43, 11 June 2024 (UTC)