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A NIH study with the acronym TACT is supportive of chelation therapy. Review articles are describing this NIH study. Perhaps a PhD scientist or physician could update the main page. "Chelation reduced adverse cardiovascular events in a post myocardial infarction (MI) population. Patients with diabetes demonstrated even greater benefit, with a number needed to treat of 6.5 patients to prevent a cardiac event over 5 years, with a 41% relative reduction in risk of a cardiac event (p = 0.0002)." a pubmed reference is PMID: 27149141
It would be very useful to include the Kd values of EDTA binding to different metals - unfortunatelly I can't find any sources
We have an insert on this page that seems to weaken the notion that EDTA bonds to divalent ions. Is one of us going to have to look up association constants for this compound in order to determine specificity? The way the text reads, you would think you could use EDTA to scavenge things like octavalent osmium. Dwmyers 16:21, 20 Sep 2003 (UTC)
Ever since I was old enough to read (which was a pretty young age), I've seen tetrasodium edta in a lot of crap. Is it easily synthesized and not toxic enough a chelating agent in its produced concentrations to worry? In sum, WTF? It's not like I'm worried about additives, but they better at least have a real purpose--how does it preserve foods, and why do we use it instead of something else?
-Todan
EDTA and its derivatives such as Disodium or Tetrasodium are not a preservative per se. They aid preservation by sequestering metal ions in solutions, and impairing bacterial growth effectively "starving" the bugs of neutrients. They make the preservative added more effective. Pedantic I know
Is there a source for the longest Scrabble word assertion? Isopropyl 04:37, 24 March 2006 (UTC)
In the Uses section, it is stated, "Note that EDTA causes lead to be relocated in the human body into the brain so its use as an antidote has been discontinued." I have never read this, is there a citation of any sort? George100 16:41, 1 June 2006 (UTC)
Can someone clean-up the "blade 2" reference in the trivia section (if it's even necessary to have this information in the acticle)? I know there's a movie, but isn't there a video game and also a TV series. Should it be "blade 2" or "Blade 2"? Also, a link to the movie/game/TV series would be useful. I've never seen that movie or the TV show or played the game otherwise I would change it myself. dq 21:53, 12 September 2006 (UTC)
The main article is seeking a citation for this - There is a good page on it at http://www.mztech.fsnet.co.uk/electrics/elc_edta.html if that helps. I have no idea how to add citations so somebody else may want to alter it.
Lawrie 13:28, 12 April 2007 (UTC)
EDTA is also used in some fertilizers, to keep iron in solution and available for plant uptake.
If anyone is interested, the IUPAC nomenclature should be 2-(carboxy(2-(carboxy(1-hydroxy-2-oxoethyl)amino)ethyl)amino)acetic acid, though I might be wrong. Just incase anyone is interested.
24.136.88.151 02:35, 4 July 2007 (UTC)
Is EDTA vegan? 66.30.67.235 13:41, 5 July 2007 (UTC)
User Edgar removed my findings on EDTA that were obtained from US government servers and are publicly available under the Freedom of Information Act. This information was removed from the page citing a copyright violation? How does information reposted from a public government server constitute a copyright violation. This seems like a deliberate attempt to suppress information regarding this compound and its increasing use in a variety of food products as a preservative. —Preceding unsigned comment added by Ianocmedia ( talk • contribs) 18:26, 3 December 2007 (UTC)
OK I understand now. Thank you for clearing up the copyright issues. —Preceding unsigned comment added by Ianocmedia ( talk • contribs) 18:36, 3 December 2007 (UTC)
Check out this FDA article. According to them, the chelator for lead is "Calcium Disodium Versenate" with the chemical name of edetate calcium disodium. The other is simply edetate disodium, marketed as Endrate. The FDA says that the former, edetate disodium, has caused 11 deaths. I think we need to make clear the distinction on this page, to clarify and help avoid future deaths. ImpIn | ( t - c) 08:46, 6 June 2008 (UTC)
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I think the article should talk about the physical properties of EDTA, such as color, solubility in water and in oil at various pH levels and temperatures, and perhaps even boiling and melting points. The solubility is especially important, because of the wide use of EDTA and its toxicity. - Pgan002 ( talk) 12:08, 21 February 2009 (UTC)
I am starting to edit this article, focusing mainly on converting lists to paragraphs. But these sections look problematic: "Widespread use of EDTA and its slow removal under many environmental conditions has led to its status as the most abundant anthropogenic compound in many European surface waters. citation needed River concentrations in Europe are reported as 10-100 μg/ L, and lake concentrations are in the 1-10 μg/L range. EDTA concentrations in U.S. groundwater receiving wastewater effluent discharge have been reported at 1-72 μg/L, and EDTA was found to be an effective tracer for effluent, with higher concentrations of EDTA corresponding to a greater percentage of reclaimed water in drinking water production wells.
EDTA is not degraded or removed during conventional wastewater treatment. However, an adjustment of pH and sludge residence time can result in almost complete mineralization of EDTA. A variety of microorganisms have been isolated from water, soils, sediments and sludges that are able to completely mineralize EDTA as a sole source of carbon, nitrogen and energy.
Recalcitrant chelating agents such as EDTA are an environmental concern predominantly because of their persistence and strong metal chelating properties. The presence of chelating agents in high concentrations in wastewaters and surface waters has the potential to remobilize heavy metals from river sediments and treated sludges, although low and environmentally relevant concentrations seem to have only a very minor influence on metal solubility. Low concentrations of chelating agents may either stimulate or decrease plankton or algae growth, while high concentrations always inhibit activity. Chelating agents are nontoxic to many forms of life on acute exposure; the effects of longer-term low-level exposure are unknown. EDTA at elevated concentrations is toxic to bacteria due to chelation of metals in the outer membrane. EDTA ingestion at high concentrations by mammals changes excretion of metals and can affect cell membrane permeability.
Other more biodegradable chelators are effective and available. For example, EDDS (S, S'-ethylenediaminedisuccinic acid) and NTA ( nitrilotriacetic acid).
-- Smokefoot ( talk) 16:15, 21 February 2009 (UTC)
in the above article,Uses in Medicine,Last entry is Use in Thalassemia Major to remove excess iron.Pl.indicate the reference of source i.e journal etc.thanks —Preceding unsigned comment added by 117.198.195.147 ( talk) 12:59, 22 April 2009 (UTC) Copied from WP:RDS Nil Einne ( talk) 13:43, 22 April 2009 (UTC)
Disodium edetate CAS no. [6381-92-6] has been added based on the following info http://www.google.com/webhp?hl=en&tab=nw#hl=en&newwindow=1&q=Disodium+edetate+International+Pharmacopoeia+site%3Awww.who.int&aq=f&oq=&aqi=&fp=fNPyysaHsgc -- 222.64.218.82 ( talk) 02:33, 18 July 2009 (UTC)
http://moldb.nihs.go.jp/jp/DetailList_en.aspx?submit=Detail(en)&keyword=Disodium+Edetate+Hydrate -- 222.64.218.82 ( talk) 00:22, 18 July 2009 (UTC)
http://www.tga.gov.au/docs/pdf/aan/aanchem.pdf -- 222.64.218.82 ( talk) 00:23, 18 July 2009 (UTC)
http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=E0399%7CSIAL&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&F=SPEC -- 222.64.218.82 ( talk) 02:38, 18 July 2009 (UTC)
This chemical is used as a
food additive in the one shown in the page of
http://www.kewpie.com.cn/mayonnaise/product03.htm
--
222.64.218.82 (
talk) 00:51, 18 July 2009 (UTC)
The company's webpage needs to be verified, as the company's address on the product label of mine is different to the one shown at their website.--
222.64.218.82 (
talk)
01:04, 18 July 2009 (UTC)
http://product.cheminfo.gov.cn/C0217/C02170101.htm -- 222.64.218.82 ( talk) 00:41, 18 July 2009 (UTC)
All the related names are confusing, especially for the food additives http://www.foodstandards.gov.au/monitoringandsurveillance/nuttab2006/onlineversionintroduction/onlineversion.cfm?&action=getFood&foodID=14B10088 -- 222.64.218.82 ( talk) 02:59, 18 July 2009 (UTC)
http://legislation.gov.au/ComLaw/Legislation/LegislativeInstrument1.nsf/framelodgmentattachments/1043D26D116E5313CA2574A50017C5A4 -- 222.64.218.82 ( talk) 03:17, 18 July 2009 (UTC)
I just edited the pKa values. Nevertheless, the values deserves a few comments:
The two lower values (0.0 and 1.5) are concidered less reliable according to my source (Harris, D.C. "Quantitative Chemical Analysis", 7th ed., W. H. Freeman and Compagny, New York, 2007).
Another source (the Combined Chemical Directory 11.2, Taylor & Francis Group 2009) states the following values at 20 °C: 0.26; 0.96; 2.02; 2.66; 6.21 and 10.31 - all in 0.1 M KNO3.
CLHA (
talk)
15:54, 20 July 2009 (UTC)
The bond-line formula shown in the png at the upper right is missing the central double bond. "Enthylene" implies a double bond. —Preceding unsigned comment added by 160.39.86.218 ( talk) 14:47, 23 July 2009 (UTC)
Didnt know where to put this question. Why does the current picture have dashes between the oxygens on two of the pairs but not on the other two pairs (out of the four pairs), or are they just not visible? also what do these dashes mean? —Preceding unsigned comment added by 138.25.80.160 ( talk) 12:47, 21 May 2010 (UTC)
I noticed that this section appears to be one large quote from a text, and have moved it here until some who knows what this is about can rewrite it. A13ean ( talk) 14:30, 27 July 2011 (UTC)
2,2',2' ',2' ' '-(ethane-1,2-diylbis(azanetriyl))tetraacetic acid - ChemDraw shorter than that one — Preceding unsigned comment added by 194.8.130.174 ( talk) 10:02, 30 March 2013 (UTC)
The result of the move request was: Not moved. EdJohnston ( talk) 02:45, 30 June 2014 (UTC)
Ethylenediaminetetraacetic acid →
EDTA – Everyone who talks about this substance calls it EDTA (saying each letter), and no one uses its full name. It is always abbreviated only as EDTA. This very common substance is widely used in science and even known to people on the edge of science, and layman audiences would definitely call this EDTA. Since this substance is EDTA both when discussed verbally and when written, it should also be the title of its Wikipedia article. --Relisted.
Armbrust
The Homunculus 08:14, 13 June 2014 (UTC)}
Blue Rasberry
(talk)
21:21, 5 June 2014 (UTC)
Generally, article naming should give priority to what the majority of English speakers would most easily recognize, with a reasonable minimum of ambiguity, while at the same time making linking to those articles easy and second nature. [emphasis added]
Acronyms should be used in a page name if the subject is known primarily by its abbreviation and that abbreviation is primarily associated with the subject.... A useful test to determine what an abbreviation usually refers to can be done by checking abbreviations.com and finding the relative usage. If it is found that a particular subject is overwhelmingly denoted by an unambiguous acronym, the article title on that subject can be expressed as the acronym.
I read the article looking for information about EDTA as a food additive. I was looking for tinned Ful medames in the UK and every brand and recipe I looked at included EDTA as a food additive to help the beans retain their colour. The label stated 'EDTA, for colour retention'. The EU number for the calcium/sodium salt is E385. 82.38.135.178 ( talk) 08:29, 28 March 2017 (UTC)
To add to the above discussion, in the literature (see e.g my recent edit today) ethylenediaminetetraacetic acid disodium salt is also referred to as EDTA. Should attention be drawn to this fact in the article's lede? LookingGlass ( talk) 08:21, 14 April 2017 (UTC)
"Strive to make each part of every article as understandable as possible to the widest audience of readers who are likely to be interested in that material.", and,
"Articles in Wikipedia should be understandable to the widest possible audience. For most articles, this means understandable to a general audience.". ' WP:ASTONISH' might be worthy of some consideration in this as well (what usage is inspiring most readers to seek out information here in the first place?). -- 75.188.199.98 ( talk) 07:50, 5 November 2017 (UTC)
"It is particularly important for the first section ... to be understandable to a broad readership. Readers need to be able to tell what an article is about, and whether they are reading the correct article, even if they don't already know the topic in detail."( WP:EXPLAINLEAD), probably has relevance here as well. -- 75.188.199.98 ( talk) 08:00, 5 November 2017 (UTC)
With respect to this text
"Non-curative minimal reversal of atherosclerosis has been claimed by therapies with iv ethylenediaminetetraacetic acid disodium salt (EDTA). EDTA has been combined with antibiotic tetracycline (comET) and has been tested with respect to infectious blood nanobacteria in therapy in patients with documented coronary artery disease (CAD). Coronary artery calcium scores decreased during ComET therapy trial in most CAD patients inferring regression of calcified coronary artery plaque volume. [1]"
This is supported by a small primary source. We need high quality secondary sources per WP:MEDRS. Doc James ( talk · contribs · email) 01:15, 15 April 2017 (UTC)
References
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The initial instances of the terms disodium EDTA and calcium disodium EDTA have been boldfaced as redirect target terms ( i.e. as terms in an article or section targeted by redirect pages; e.g. Disodium EDTA and Calcium disodium EDTA)—a practice recommended by WP:R#ASTONISH, Wikipedia:Manual of Style/Text formatting#Other uses, and MOS:BOLD#Article title terms—so as to help orient readers arriving from redirect links elsewhere and as an example of best practice inline with Wikipedia policy and guidelines.
This is also done, at the first occurrence in running text, of a term that's redirected to the article or one of its sub-sections, whether the term appears in the lead or not.
— MOS:BOLD
Thanks for your time and attention, -- A Fellow Editor ( talk) 18:22, 25 November 2017 (UTC)
Are you sure about Cr, I think it is another element
--the good K-- — Preceding unsigned comment added by 46.189.28.44 ( talk) 14:47, 12 February 2018 (UTC)
The following Wikimedia Commons file used on this page has been nominated for deletion:
Participate in the deletion discussion at the nomination page. — Community Tech bot ( talk) 14:51, 15 November 2019 (UTC)
https://www.sciencedirect.com/science/article/pii/S0306987720312007 Medical Hypotheses
Volume 144, November 2020, 110027
Title: Why the lower reported prevalence of asthma in patients diagnosed with COVID-19 validates repurposing EDTA solutions to prevent and manage treat COVID-19 disease
-- ee1518 ( talk) 11:32, 14 October 2020 (UTC)
I removed this sentence from the alternative medicine section: “Although, U.S. medical associations — including the American College for Advancement in Medicine (ACAM) are dedicated to training doctors in the use of chelation therapy to improve hardening of the arteries and other chronic degenerative issues.” The justification for removal is that not only is the material is unsourced, it also implies that chelation therapy is effective against cardiovascular disease by saying that “U.S. medical associations” are training doctors in chelation therapy. Using the term “U.S. medical association” alone when referring to the ACAM, although true, is possibly deceptive because it implies that the ACAM is close to the medical establishment and likely a respected institution, without providing much information about it. In terms of how respected it is, it doesn’t appear to have a Wikipedia page, but here’s some text from the page Chelation therapy: “In 1998, the U.S. Federal Trade Commission (FTC) charged that the web site of the American College for Advancement in Medicine (ACAM) and a brochure they published had made false or unsubstantiated claims. In December 1998, the FTC announced that it had secured a consent agreement barring ACAM from making unsubstantiated advertising claims that chelation therapy is effective against atherosclerosis or any other disease of the circulatory system.” Also on that page: “According to the findings of a 1997 systematic review, EDTA chelation therapy is not effective as a treatment for coronary artery disease and this use is not approved in the United States by the US Food and Drug Administration (FDA).” Notably, that page also contains a pro- ACAM paragraph, but given the preponderance of well- cited material on that page against chelation therapy, that paragraph seems less like a counterpoint than evidence that proponents of chelation therapy as a method to treat cardiovascular disease have added deceptive material to several Wikipedia pages.
The reason I wrote this whole paragraph was to have a solid bulwark to stand on to explain this removal, both so that bystander editors will understand why this sentence was removed, and, more importantly, as a defense should the pseudosciencechelationists, who appear to have some real power on Wikipedia, challenge this edit and attempt to restore either the original sentence or some more well- disguised version. MaroonDichotomy ( talk) 07:56, 3 September 2022 (UTC)
ronitkumar079035@gmail 157.47.15.9 ( talk) 15:49, 29 December 2022 (UTC)
Recently slug pellets using iron phosphate and EDTA have come onto the market, the claimed mechanism is the chelating agent causes the otherwise insoluble iron ions to kill slugs that ingest them from iron poisoning. Perhaps someone could write a bit under uses for this. 90.247.227.132 ( talk) 18:37, 30 April 2023 (UTC)