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This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 May 2021 and 6 August 2021. Further details are available
on the course page. Student editor(s):
M4c9s0.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 19:44, 16 January 2022 (UTC)
I brought up a question on the tuberoinfundibular pathway talk page, but that may be less likely to be seen than here, the more general subject, my question was what the term "Mesotelencephalic system" would be referring to? Nagelfar ( talk) 13:14, 27 October 2009 (UTC)
"The neuron's soma produces the dopamine, which is then transmitted via the projecting axons to their synaptic destinations." Really? I always thought that dopamine (and other mono amines) are synthesized near the axon terminal. Litawor ( talk) 21:28, 4 July 2011 (UTC)
I thought Dopamine Circuits relates to the physical structures while dopamine pathways has to do with the patterns of thinking used to experience it...? If not, then what is the term used for the behaviors and thought patterns, or orchestration of meanings, we use to focus the experience of dopamine? Thanks, OasisMike I've learned a new way of thinking. ( talk) 13:59, 31 October 2012 (UTC)
@ Petergstrom: You need to stop being so defensive of content that you add and start listening to constructive criticism, because trying to fix issues with inaccuracy (verifiability) that you repeatedly introduce is seriously annoying me. This table is not accurate because it suggests uniformity in the inputs to every brain structure which contains dopaminergic nuclei, it's not comprehensive because it's missing important inputs to the VTA (e.g., orexinergic projections from the lateral hypothalamus; that said, I have to give you credit for covering the GABAergic inputs from the RMTg - the importance of that nucleus was identified only recently so a number of refs don't cover it) and other dopaminergic cell groups, and most important of all, it fails verification because the source you cited literally illustrates that the inputs to the VTA and SNc are not uniform in a diagram.
I am not deleting the table because I think that this content should not be covered. I am deleting it because you are not accurately covering this content in a manner that is consistent with the cited source and other neuroscience reviews on this topic. Inputs are usually covered in articles on brain structures, not neural pathways, but that convention doesn't mean that this content shouldn't be added in this article. If you want to add it here, cover this material correctly by partitioning the inputs according to each dopaminergic projection nucleus: [1]
These cell groups are the dopaminergic nuclei that give rise to every dopaminergic pathway in the brain. This article currently covers most of the pathways associated with cell groups A9 through A15.
Lastly, the only neurochemicals in that table that only function as excitatory neurotransmitters and inhibitory neurotransmitters are glutamate and GABA, respectively. Do not generalize or make inferences from sources based upon what you read - doing this constitutes WP:OR. The only way to ensure that you do not violate that policy is by accurately paraphrasing content from the sources you cite so that the content you add is directly supported by its source.
If you intend to continue writing content on complex topics in neuroscience, you need to pay more attention to the details of the sources you cite and generalize a lot less than you have been in order to ensure that the content you write is accurate; otherwise, I'm very likely going to end up having to revert or heavily revise your additions. If you want to have a broader discussion about this, I'm open to seeking input from WT:NEURO. Seppi333 ( Insert 2¢) 22:02, 18 January 2017 (UTC)
The locus coeruleus and other noradrenergic nuclei in the medulla give rise to norepinephrine (NE)-containing terminals in the VTA/SNc (Phillipson, 1979, Mejias-Aponte et al., 2009). Overall, NE exerts excitatory control over DA neuron activity via activation of α1 adrenergic receptors, causing membrane depolarization, or suppressing the mGluR-induced pause (Grenhoff et al., 1995, Paladini et al., 2001). However, transient activation of α1 adrenergic receptors produces SK-mediated membrane hyperpolarization (Paladini and Williams, 2004). NE can also bind to D2 DA receptors and cause membrane hyperpolarization in DA neurons (Grenhoff et al., 1995, Guiard et al., 2008).
Actually overall is not a transition word- apparently, you are wrong. Seppi333 ( Insert 2¢) 01:16, 19 January 2017 (UTC)
"Dopamine neurons have axons that run the entire length of the pathway." [1] I would like to find a citation for this statement. M4c9s0 ( talk) 04:19, 30 May 2021 (UTC)
References
I am considering adding to this article with information from:
Principles of neural science. Eric R. Kandel, John Koester, Sarah Mack, Steven Siegelbaum (Sixth edition ed.). New York. 2021. ISBN 978-1-259-64223-4. OCLC 1199587061. M4c9s0 ( talk) 04:29, 30 May 2021 (UTC)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2022 and 7 December 2022. Further details are available
on the course page. Student editor(s):
Denisej 2 (
article contribs). Peer reviewers:
Eresha8,
Birmaniahern,
Hkhan11.
— Assignment last updated by Hkhan11 ( talk) 00:43, 2 October 2022 (UTC)
"glutaminergic" should read "glutamatergic". (Yes, the latter and former are enzymatically interconverted, but it's glutamATE that does the neurotransmitting. Glutamine is banked intracellularlyrve for rapid glutamate synthesis aprovidesfor a source of amino groups to synthesize other amino acids when necessary.) 2600:1700:5D52:530:5414:288:706D:47BA ( talk) 02:37, 28 January 2024 (UTC)