Chlorpromazine was a Natural sciences good articles nominee, but did not meet the
good article criteria at the time. There may be suggestions below for improving the article. Once these issues have been addressed, the article can be
renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.
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I don't think the term "Lunatic Asylums" is an appropriate term for psychiatric hospitals. It is not a factual term, but rather a derogatory one. It is not a neutral term either, as it has very negative connotations.
"Common uses" text just seems to be a lot of opinion.
The extensive use of single in double quotes in the first paragraph under "Common uses" did not improve my confidence in the information I was trying to look up. Is this necessary, or all of these sneer quotes?
66.92.73.21707:27, 10 March 2007 (UTC)reply
I wanted to clarify same confusion over the brand names. In Canada we have Chlorpromazine, also known as Largactil. Stemetil is actually Prochlorperazine. This could be potentially error causing.
For covering a drug that's been in use for nearly 60 years, this article has VERY few citations. Is there anybody who wants to tackle this problem? --
Aurochs (
Talk |
Block)
Thorazine and Brain Rot
"Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ, is a highly toxic drug used to sedate and control patients, making them compliant while rotting their minds."
Anyone know the story with this line in the introduction? Smells like vandalism to me.
SignsFollowing (
talk)
22:14, 17 June 2010 (UTC)reply
Dang, I meant to improve this article myself sometime. Nevermind, I'll review it. I'll make straightforward changes as I go and try and give it a shove towards FA while I'm at it. I'll jot queries below:
Casliber (
talk·contribs)
21:39, 6 July 2010 (UTC)reply
We call it largactil in oz. maybe it is called that elsewhere outside US so would be better in lead?
Subcutaneous injection is not advised.. - intramuscular is a more common way of giving injections like this - we don't do it anyway as it has a highly unpredictable uptake (I am a psychiatrist BTW :))
Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. - issues (1) extrapyramidal side effects and tardive dyskinesia of CPZ are less than other typical antipsychotics, so I am not sure that 'severe' is a good adjective to add. (2) I am not sure whether it was the side effects, but being parlty superseded by thioridazine and later olanzapine were more the issue, and I am not sure if it was the 1960s when its use declined. In any case, this needs checking, citing and expanding. I am intrigued and will look into it if I get a chance.
Casliber (
talk·contribs)
10:06, 7 July 2010 (UTC)reply
I changed this because I don't think it's right. There were several drugs that came shortly after that had worse side effects, like haloperidol, I believe. I think its use declined because other more efficacious drugs were developed.
MacDaid (
talk)
18:05, 7 July 2010 (UTC)reply
From chlorpromazine a number of other similar antipsychotics were developed such as triflupromazine and trifluoperazine. - as per previous, needs checking, citing and expanding. Not sure if these are the correct drugs or the only drugs.
I have removed this information, as it is not found elsewhere and is not necessary to the understanding of chlorpromazine.
MacDaid (
talk)
15:20, 8 July 2010 (UTC)reply
the Dosage and administration section needs referencing.
As above, except for drug sites and repeated references to Goodman and Gilman (which a hard-to-read copy is online), there don't seem to be many sources. PMID etc have mostly articles on rats, and old ones at that. I get the feeling this is not a current area of active research.
MacDaid (
talk)
18:05, 7 July 2010 (UTC)reply
The inline refs which use drugs.com need replacing with a proper Review Paper. Some are dubious or misworded - eg. some cases of impaired glucose tolerance may have been reported but this is very rare, especially when compared with some other agents.
Since you are a psychiatrist, perhaps you can comment on some of the specialized sections, such as "Dosage and administration" and "Pharmacology" sections. Some information is sourced to Drugs and behavior: an introduction to behavioral pharmacology and may be general information not specific to chlorpromazine. Is chlorpromazine ever used as a depot medication? (I wouldn't think so, but I don't know.) I removed some information that seemed too general, such as how to dissolve chlorpromazine in oil to prepare it for IM administration. What do you think?
MacDaid (
talk)
17:55, 8 July 2010 (UTC)reply
Yeah, I agree with the removal of information such as how to mix it up for an IM injection. My free time has just been all over the place the last few days. I will have a read-through now. Sorry I haven't been more all over this one.
Casliber (
talk·contribs)
01:38, 9 July 2010 (UTC)reply
I have to run but google "CPZE" (I might do this myself a bit later today if I get time) and look at 3rd entry (I can't get up the url as it flicks up into acrobat reader in pdf fromat) - there are some papers detailing the usage of the term -look at the reference section of that paper. Important as CPZ used as scale for other anitpsychotics.
Casliber (
talk·contribs)
01:47, 9 July 2010 (UTC)reply
Yeah, I saw that one. I meant to say I was going to check some of the refs listed in that one which discuss the development of the term...before I got sidetracked.
Casliber (
talk·contribs)
20:58, 9 July 2010 (UTC)reply
Chlorpromazine is never used as a depot. The intramuscular injection is highly unreliable and can vary considerably in its potency (as well as being painful), and is almost never used. Intravenous administration can cause a big drop in blood pressure, so never done either. It is often administered as a syrup in hospital as it works a little quicker than tablets and patients can't spit it out as easily (the same issue has been tackled differently by the makers of risperidone and olanzapine, both of which come in wafers which dissolve on the tongue.)
Casliber (
talk·contribs)
14:12, 17 July 2010 (UTC)reply
The dosage section needs rejigging - generally 25 mg is used for hiccups or anxiety. It is usually ineffectual in psychosis though, where people will be on anywhere from 100 mg nocte upwards. In the acutely agitated inpatient, it is often given early on twice or three times daily to take advantage of calming effect through the day, and it may also be used as a PRN medication for agitation (50-100 mg). Once a patient is more settled, one can shift the dosing to all at night before bed, to take advantage of the sedation to get to sleep and minimise its impact on daytime alertness. Higher doses, up to 1200 mg daily or higher were used 30 years ago. Nowadays the dosing is much lower. Need to find a ref for maximum but is rare to see someone above 300 mg daily.
Casliber (
talk·contribs)
14:28, 17 July 2010 (UTC)reply
Compared to the information available elsewhere, this article fails as a good article. Compared with other Wikipedia articles, the standard is lower so it could pass. I caution others not to pat ourselves on the back and be too quick to call this GA. This pains me because I generally like to be positive in Wikipedia. One helpful thing to have would be a review by a pharmacologist. Otherwise it is amateurs reviewing things written by amateurs.
One of many problems is that there is a negative bent to the article. In government package inserts, the possible side effects are near the end. Here, it is in the beginning and also near the end. There is also a lot of negative emphasis. This could be partly fixed by moving sections around but complete repair requires major re-writing.
I agree with the above. I had ferreted out a couple of papers I am going to add. I have been busy elsewhere. But will work on it too, as well as list out more specific issues.
Casliber (
talk·contribs)
22:29, 31 July 2010 (UTC)reply
Since the article's main editor has since been indefblocked, it is best to fail the article, which I'm going to do. It can be re-nommed after all the issues are fixed, since it looks like it'll be a while until that happens based on the above.
WizardmanOperation Big Bear18:36, 8 August 2010 (UTC)reply
There is no section, or information, in the article regarding matters such as the original mamnufacturer, who got it through FDA etc etc. I think this information is as important and relevant as the scientific data.
LookingGlass (
talk)
07:00, 16 July 2012 (UTC)reply
The article specifies the year of discovery as 1951 but the Tricyclic Antidepressants article claims it was synthesized in December of 1950. I suppose "discovery" here may refer to publication; still seems a bit odd.
Lewis Goudy (
talk)
16:53, 29 August 2016 (UTC)reply
This section lists chemical building blocks for this pharmaceutical. I added links to these chemicals so someone can start and article on these chemicals. It is very important to get to the root of how these pharmaceuticals are made. Are they made from petrochemicals?
2602:306:C518:62C0:74DE:981B:CE5E:4DE0 (
talk)
00:30, 23 July 2012 (UTC)reply
Chemical Straight Jacket
Thorazine is a drug with a storied history in the community at large. This should be included in this article.
The term "Chemical Straight Jacket" is acknowledged in this college level textbook copyright 2012:
Benzene is a petrochemical and a component of gasoline and is a carcinogen. Crude Oil is the ancient feces of the dinosaurs and it is true the medicine is made out of feces.
108.81.134.196 (
talk)
01:23, 8 May 2013 (UTC)reply
chlorpromazine has been largely superseded by the newer atypical antipsychotics,
This is only the case in the affluent west. In many part of africa, it is the only affordable ant-psychotic and is also used in injectable form as a rapid tranquilliser, frquently combined with IV diazepam. — Preceding
unsigned comment added by
Saklein (
talk •
contribs) 10:21, 20 April 2014 (UTC)
It's still common in United states used as a injection or a pill for psychotic disorders of the mind — Preceding
unsigned comment added by
A8v (
talk •
contribs)
10:00, 15 July 2015 (UTC)reply
US generic cost
Can somebody explain why the quoted cost of generic versions of this drug is much higher in the US than elsewhere? This seems nuts. Surely drugs which are out of patent can be freely traded worldwide, so the generic price should be more or less the same everywhere. I've noticed the same thing in other drug articles. Is this something to do with FDA licensing, or is it simple protectionism at the cost of the patient? --
Ef80 (
talk)
22:03, 24 March 2016 (UTC)reply
Jytdog, I have no axe to grind in this matter and am not American. I certainly don't want to discuss the subject on WP talk pages. The article currently quotes completely different generic prices for the US and elsewhere without explanation, and this needs clarification. --
Ef80 (
talk)
00:31, 26 March 2016 (UTC)reply
"Thorazine shuffle" redirection
I just wanted to point out that "Thorazine shuffle" redirects to this page, which never mentions "Thorazine shuffle" except in one note that states that "Thorazine shuffle" redirects to it. This is not particularly informative.
66.76.242.44 (
talk)
22:53, 14 November 2017 (UTC)reply
Yes the sources are really too old. As a first generation antipsychotic, it's also expected that there can be more serious side effects than with some more recent molecules, but the article already mentions them. —
PaleoNeonate –
12:16, 16 March 2021 (UTC)reply
True, I may even grant the point that that was true about medicines from the 1970s, but it is begging the question that it is true about medicines from 2020s.
Tgeorgescu (
talk)
21:03, 16 March 2021 (UTC)reply