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Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 6 January 2020 and 25 April 2020. Further details are available
on the course page. Student editor(s):
Julianaquintero0917.
Will be making significant changes to this article in the hours ahead (as part of a college course a graduate course in cancer biology). Plan is to restructure the article using the following:
Defining Cancer Biomarkers
Role of Biomarkers in Cancer Research and Medicine
Uses of Biomarkers in Cancer Medicine
Risk Assessment
Diagnosis
Prognosis
Prediction of Treatment Response
Pharmacokinetics
Monitoring Treatment Responses
Recurrence
Uses of Biomarkers in Cancer Drug Discovery
Developing Drug Targets
Surrogate Endpoints
Biomarkers by Cancer Type
Breast Cancer
Prostate Cancer
Ovarian Cancer
Stomach Cancer
Lung Cancer
Colon Cancer
Melanoma
Non-Hodgkin Lymphoma
Methods for Cancer Biomarker Discovery
Genomics
Proteomics
Metabolomics
Molecular Imaging
In Silico
Challenges for Biomarker Adoption in Cancer Care — Preceding
unsigned comment added by
Afhaque (
talk •
contribs)
Great! Before you dig in too deep please look at
WP:MEDRS to see our standards for sourcing biomedical information. It looks like you are already using secondary sources (Review articles and the like) from MEDLINE-indexed journals so definitely keep that up. We generally altogether avoid primary sources (individual studies) in our medical articles. Also see
WP:MEDMOS for our guidelines on how medical articles are structured. But also just feel free to add content and worry about formatting later. The two most important rules are: Use great sourcing (see
WP:MEDRS) and do not plagiarize (can't copy and paste from abstracts or textbooks, etc.). Happy editing! Zad6803:59, 26 April 2013 (UTC)reply
Thanks for the input (and warning) Zad! I wasn't too sure if Wiki liked having reviews or original articles. I guess I sort of lucked out that I've mainly been using reviews throughout.
Afhaque (
talk)
11:13, 26 April 2013 (UTC)reply
- As the articles are written now, there is considerable overlap between this page (Cancer Biomarkers) and Tumor Markers. Both have, however, a vital function in Wikipedia. therefore, in my view this article (Cancer Biomarkers) should be re-written and possibly re-named to clarify the limits.
As I see it, the term Tumor Markers is used for functional proteins and conjugated proteins (antibodies, enzymes), antigens or antigen fragments (particularly surface antigens), hormones, cell debris (for instance degraded cytokeratins) that have either ended up in the circulation in the course of a cancer process or can be demonstrated in unnatural quantities in tissue by histology. They are used either by clinical-chemical methods in body fluids or histologically in tissues. Sometimes they have been considered also for treatment, for instance with "magic bullets" or as targets for immunization. Tumor markers does not include genetic markers.
Cancer biomarkers, on the other hand, is typically used for genetic markers. They may be genes that pre-dispose for malignancy or markers that result from malignant changes of the genetic or paragenetic set-up of given cells and form the origin of malignant growth, by themselves of together with other unfortunate changes in the cells.
My suggestion is therefore that this article Cancer Biomarkers includes a limiting definition of the scope (this or some other suitable) and is re-written in accordance with a link to the article Tumor Markers and the article Tumor Markers is re-written with a corresponding definition of its scope, a link to this article and is re-written to include information found in this article that falls within the scope of Tumor Markers, and also to be up-dated and completed (needs complete revision).
I will be happy to do part of the job, but first let us agree who is doing what, not to duplicate the jobs.
I think it may be good to add info about these three and maybe similar developments to relevant articles (possibly the ones wikilinked):
Progress in cancer pre-screening,
screening and early detection is reported:
metabolomicbiomarkers in blood (4 J.),[1][2] circulating proteins biomarkers (7 J.),[3][4] and an optical
biopsy system with a fine-needle probe (6 J.).[5][6]
It's currently featured like above in
2022 in science (January).
I'm not sure if, where and how it would be most due. For instance, these three studies/results/developments may be too specific to add as is to their respective most relevant articles and would need some broader info (as in what Natureium said above).
I think Wikipedia articles should be up-to-date with relevant adequately-integrated brief scientific information. Please comment if you have any feedback or idea about
if, where and how info about these three studies and their broader topics (these could then be examples) should get added, or
if, where and how info about such cancer research progress more generally should get added, or
=> A timeline article for biomarkers may not be the best approach, but I think enabling such, including on Wikipedia (e.g. it could also be enabled via
Scholia and/or a dedicated collaborative biomarkers/screening database website), could still be useful and appropriate – for example a table with a column for the date could also be sorted by the date to show progress chronologically (rows with nonviable biomarkers and/or cancer screening progress could get trimmed).
=> It could also be added to a new article like
Cancer screening research that is parallel and similar to
Spinal cord injury research. Note that it should be maintained and use scientific reviews whenever possible. I won't create any such article and would at most add a few updates to it.
The February section of the
2022 in science article currently has this:
^Larkin, James R.; Anthony, Susan; Johanssen, Vanessa A.; Yeo, Tianrong; Sealey, Megan; Yates, Abi G.; Smith, Claire Friedemann; Claridge, Timothy D. W.; Nicholson, Brian D.; Moreland, Julie-Ann; Gleeson, Fergus; Sibson, Nicola R.; Anthony, Daniel C.; Probert, Fay (4 January 2022). "Metabolomic Biomarkers in Blood Samples Identify Cancers in a Mixed Population of Patients with Nonspecific Symptoms". Clinical Cancer Research.
doi:
10.1158/1078-0432.CCR-21-2855.
ISSN1078-0432.
^Wald, Nicholas J; Bestwick, Jonathan P; Morris, Joan K. "Multi-marker risk-based screening for prostate cancer". Journal of Medical Screening.
doi:
10.1177/09691413221076415.
^Xu, Rong; Rai, Alin; Chen, Maoshan; Suwakulsiri, Wittaya; Greening, David W.; Simpson, Richard J. (October 2018). "Extracellular vesicles in cancer — implications for future improvements in cancer care". Nature Reviews Clinical Oncology. 15 (10): 617–638.
doi:
10.1038/s41571-018-0036-9.
ISSN1759-4782.