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BER does not occur only during replication! It can occur throughout the cell cycle and is important to repair single-strand breaks before replication so that they don't result in lethal double-strand breaks. —Preceding unsigned comment added by 130.237.85.123 ( talk) 13:29, 11 March 2008 (UTC)
betty, 25 Januar 2009
the article is not clearly arranged. Maybe a scheme about the single glycosylases would be more instructive. And a figure about the basic mechanism would be nice ,too. thanks! —Preceding unsigned comment added by 193.174.73.60 ( talk) 15:36, 25 January 2009 (UTC)
The short and long pair repair section should actually belong here, not in DNA mismatch repair Temporal User ( Talk) 05:37, 11 February 2009 (UTC)
I don't agree. Short patch in MMR is 10 nucleotides and long patch is a few kbases, while BER short patch is 1 nucleotide and long patch is no longer than 15 nucleotides. They are clearly different and as far as I know they MMR is coupled to replication and don't involve any of the BER proteins. Sniffe35 ( talk) 11:56, 17 February 2009 (UTC)
Perhaps we should divide the section of glycosylases into bifunctional and monofunctional? I'll help update this article when I have more time! It is desperately in need of a section about DNA synthesis and ligation... Single-strand break repair needs to be mentioned here, as well as end processing enzymes and APE1. Sniffe35 ( talk) 16:02, 28 April 2009 (UTC)
Over the last few days I've done a major rewrite of this article to address the above issues. I tried to make the article into more of an overview (previously it had a lot of detailed information on specific glycosylases but little overview-type material on the pathway as a whole that would be more appropriate for an encyclopedia). Please take a look at it and make suggestions here if there's anything you'd like to see added/removed/expanded/etc. If anyone wants to help with adding references please jump in! Amazinglarry ( talk) 21:06, 15 July 2009 (UTC)
Which organisms do BER? Which parts of it? Exceptions? Importance in organims in highly oxidative environments, redundancies there. -- Ayacop ( talk) 15:04, 8 August 2011 (UTC)
As well as mentioning Parp1, as suggested above, should we also mention Aag as per
How to minimize the side effects of cancer treatment. Also
Defining the functional footprint for recognition and repair of deaminated DNA.
alkyladenine glycosylase is mentioned in
deamination but not here. -
Rod57 (
talk)
15:26, 7 April 2013 (UTC)