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Acetylcholine is also used as a medication for intraocular injection under the trade name Miochol or Miochol-E. It's used during glaucoma or cataract surgery, I believe, to induce miosis (constriction of the pupils). Could someone add this to the page? —Preceding unsigned comment added by 72.175.42.232 ( talk) 03:52, 10 December 2008 (UTC)
I have found a number of articles that discuss the side effects of withdrawl from antidepressants, such as Paxil. These articles refer to a disruption in the body's production of aetylcholine as a key instigator of the withdrawl symptoms. I am hoping that someone with the appropriate medical qualifications could include a discussion of such withdrawl symptoms and their relationship with aetylcholine in the article. (ie: http://bipolar.about.com/cs/antidep/a/0207_ssridisc1.htm)
The article states that acetylcholine is an ester of acetic acid and choline. I am not a chemist so I am unclear how the ruling is on this issue, but in order to state that acetylcholine is an ester of acetic acid and choline, does this presuppose that acetylcholine is synthesized from acetic acid and choline? Because, after reviewing the literature, the origin of the acetyl moiety is most likey from glucose or pyruviate. Niubrad ( talk) 12:56, 23 June 2008 (UTC)
Would like to see this article go more in-depth on how Acetylcholine is synthesized, stored, and transported. This would include ACh being transported into the storage vesicle VAT and brought to cleft after influx of intracellular Calcium. Gsangiuliano24 ( talk) 23:27, 17 September 2020 (UTC)
May someone please tell me how does the acetylcholine decrease the heart rate? It is obvious that is slows the heart down, but how? What caused that slowing down of the hear rate? -Unknown
Muscarinic receptors mainly have an IPSP (inhibitory post-synaptic potential) meaning they slow down/inhibit the action of what they are on. Acetylcholine can bind to these or to nicotinic receptors (which can create an EPSP - excitatory potential) which has the reverse effect. - E.H. —Preceding unsigned comment added by 69.157.100.79 ( talk) 04:12, 2 October 2007 (UTC)
Acetylcholine -- beneficial or detrimental? I've read both that acetylcholine is beneficial for preventing conditions such as Alzheimer's, but also that acetylcholine may promote tumor growth. Is the choice between cancer and dementia? -- Thoric 22:06, 3 Jun 2005 (UTC)
It says that Acetylcholine binds to the Ach Receptors in muscle cells and causes release of Sodium ions causing the muscle to contract, but that's not what my anatomy textbook says about it (and it was released just last year!), it says that it causes release of Calcium ions. Should I change this or delete that statement or what? Miroku Sanna 22:14, 12 November 2005 (UTC)
-Unknown
Is it possible to add a chapter that explains what acetylcholine is and does in easier words? Thanks, -- Abdull 20:34, 20 April 2006 (UTC)
But this is not all. A. is also a very important neurotransmitter in the brain. In the quantity it is after glutamatic and gaba one of the higest concentrated neurotransmitter. It is necessary for memory and concentration. You need it for learning. Acetylcholine influences positive mood and drive. With deanol or centrophenoxin/meclophenoxat, you can enhance this. - Fackel 21:55, 30 May 2006 (UTC)
I've added a section on neuromodulatory effects of ACh. The information came from the Hasselmo (1995) paper I added to the reference (including a link to a pdf online, I hope that's an acceptable thing to do). —The preceding unsigned comment was added by Digfarenough ( talk • contribs).
The sentence in the introduction,
may have been quoted from here: Lymenet raptor 10:29, 7 September 2006 (UTC)
The article makes no mention of the relationship between ACh and memory. I don't know specifically what the relationship is, but only that it supposedly plays "a vital role in learning and memory" (p. 52, Psychology, 6th Edition, David G. Myers).
I note that the Nitrogen end of the molecule has 3 methyl groups instead of 2 (and an electron pair, like most organo-nitrogen compounds do). How is this possible?—Preceding unsigned comment added by 12.41.204.3 ( talk • contribs)
The link "Yu, AJ & Dayan, P (2005). Uncertainty, neuromodulation, and attention. Neuron 46 681-692. [2]" points to a different paper. The quoted paper is in PubMed, not free online. 83.132.182.27 02:13, 28 December 2006 (UTC)
"by decreasing the conductange of voltage-dependent M currents and Ca2+-dependent K+ currents." Conductange or conductance? What is M currents? There is no category in wikipedia with this name. Jlpdca 02:24, 30 December 2006 (UTC)
The Yu and Dayan citation appears in Decision Making. This whole section is vague and unreferenced (except for the broken Yu and Dayan). I would like to replace this with a section on Memory, which is under reported, if no-one objects. Mountain9 ( talk) 19:54, 22 December 2016 (UTC)
I was reading about this chemical and this article doesn't reflect what I read, could it be added or is it wrong? [1] It seems that Acetylcholine plays a role in contracting the muscles of the digestive system, whereas adrenalin relaxes them. It's pretty strange how it is also used to contract the skeletal muscles, but not the cardiac muscles. If anything you'd think the smooth muscle tissue of the heart would be more similar to one of them. As adrenaline is used in fight or flight to stop digestion (recuperation) and turn into a catabolic state, I'm guessing adrenalin does not similarly relax the skeletal muscles, and that Ach must have some sort of local effect so that when either digestion or skeletal muscle exertion occur the other does not simultaneously also do so. Tyciol 17:04, 23 March 2007 (UTC)
The smoking cessation aid
RonEJ / talk 02:25, 13 April 2007 (UTC)
Is THC really an anticholinesterase. I couldn't find evidence to support this, and the claim is not referenced. It is under Alzheimer's on this page. perhaps someone could remove or reference it. —Preceding unsigned comment added by Aleph Mercure ( talk • contribs) 11:13, 8 January 2008 (UTC)
Is there any reason for excluding the category "neurotransmitters"? Acetylcholine is a neurotransmitter.-- Miguelferig ( talk) 21:19, 4 August 2012 (UTC)
I think the emphasis on acetylcholine in the CNS as being a neuromodulator is unbalanced. It is both a neurotransmitter and a neuromodulator but the emphasis is strange. I'm not sure how best to fix this. Mountain9 ( talk) 20:48, 21 December 2016 (UTC)
The text indicates that various substances can either stimulate or inhibit ACh receptors in a dose dependant fashion, however it neither offers a citation, nor indicates the does. With substances such as Acetl-L-Carnitine where people may self medicate, this information is vital. — Preceding unsigned comment added by Leopardtail ( talk • contribs) 15:20, 16 May 2014 (UTC)
The comment(s) below were originally left at Talk:Acetylcholine/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
I came to this page to look for effects of Acetylcholine related to "flight or fight" responses. I found the page to be pretty jargony and didn't find the answer I was looking for. 216.162.200.203 ( talk) 22:14, 30 July 2009 (UTC) |
Last edited at 22:14, 30 July 2009 (UTC). Substituted at 06:36, 29 April 2016 (UTC)
Central nervous system[edit]
In the central nervous system, ACh has a variety of effects as a neuromodulator upon plasticity, arousal and reward. ACh has an important role in the enhancement of alertness when we wake up[2], in sustaining attention[3]and in learning and memory.[4] Damage to the chlorine(acetylcholine-producing) system in the brain has been shown to be associated with the Jonhorridge ( talk) 20:21, 21 December 2016 (UTC)
I think chlorine should be cholinergic but I didn't write the original so I'm not sure what was intended. Cholinergic would make sense. Mountain9 ( talk) 20:44, 21 December 2016 (UTC)
How does choline bitartrate (commonly hyped as a nootropic) fit into choline chemistry? Kortoso ( talk) 20:52, 22 March 2017 (UTC)
I was just reading in the Wikipedia article on hornets that certain species' venom is spiked with acetylcholine which greatly enhances the potency of their venom. Perhaps this could be worked into this article somewhere. Ealtram ( talk) 17:59, 29 March 2017 (UTC)