Transcriptional adapter 3-like is a
protein that in humans is encoded by the TADA3gene.[4][5][6] Cytogenetic location: 3p25.3 [7]
Function
Many
DNA-binding transcriptional activator
proteins enhance the initiation rate of
RNA polymerase II-mediated
gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to
acetylate and destabilize
nucleosomes, thereby relieving
chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the
PCAF histone acetylase complex. In addition, it associates with the tumor suppressor protein
p53 and is required for full activity of p53 and p53-mediated
apoptosis. At least four
alternatively spliced variants have been found for this gene, but the full-length nature of some variants has not been determined.[6]
^Sulimova G, Kutsenko A, Rakhmanaliev E, Udina I, Kompaniytsev A, Protopopov A, Moisjak E, Klimov E, Muravenko O, Zelenin A, Braga E, Kashuba V, Zabarovsky E, Kisselev L (2002). "Human chromosome 3: integration of 60 NotI clones into a physical and gene map". Cytogenetic and Genome Research. 98 (2–3): 177–183.
doi:
10.1159/000069814.
PMID12698000.
S2CID41010053.
^
abRual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID16189514.
S2CID4427026.