SC 300 begins at
US 278 south of
Barnwell and heads in a southeasterly direction, crossing over Hurricane Creek and Parker Branch. It runs parallel with Caddins Branch through a small subdivision before it crosses over Wells Branch, leaving
Barnwell County. It becomes Wells Branch Road as it enters
Allendale County before passing by Dry Branch Hunting Reserve before it enters the
Ulmer city limits. The highway then meets its southern terminus at
US 301 (Burton's Ferry Highway) west of Ulmer.[3]