SC 67 begins at an
intersection with
U.S. Route 378 (US 378) in Sumter National Forest, east-northeast of
McCormick, within Edgefield County. South of US 378, the roadway continues as Walker Road. It travels in a fairly northern direction through
rural areas of the county. About one mile (1.6 km) later, it enters McCormick County. The highway only travels about three miles (4.8 km) through McCormick County before it enters Greenwood County. When SC 67 leaves the national forest, it passes through
Callison. The highway keeps traveling through rural areas until it meets its northern terminus, an intersection with
US 25/
US 178, south-southeast of
Greenwood.[4]