SC 269 begins at an
intersection with
SC 215 (Monticello Road) near
Blythewood, Richland County. It travels to the north and curves to the north-northwest and enters Fairfield County. It curves to the north-northeast and the northeast and passes the
Fairfield County Airport. A short distance later, it meets its northern terminus, an intersection with
U.S. Route 321 (US 321) at a point south of
Winnsboro Mills.[3]