SC 172 begins at an
intersection with
U.S. Route 178 (US 178; North Road) east-northeast of
North, within Orangeburg County. It travels to the north-northeast. Approximately 1,000 feet (300 m) later, it meets the eastern terminus of
SC 692, with SC 172 heading to the east-northeast before it enters Calhoun County. It passes by the
Do-Little Field airport just before it meets
US 21 (Columbia Road). SC 172 continues another 0.09 miles (0.14 km) to end at
SC 6 (Caw Caw Road).[3]