From Wikipedia, the free encyclopedia
Sjors Hendrik Willem Scheres
FRS (born 1975) is a Dutch scientist at the
MRC Laboratory of Molecular Biology Cambridge, UK.
[1]
[2]
Education
Scheres studied Chemistry at
Utrecht University in The Netherlands, and spent nine months at the
European Synchrotron Radiation Facility in France for his undergraduate research thesis. He then came back to
Utrecht University for his
DPhil in
Protein Crystallography ,
[3] which was supervised by
Piet Gros .
Career
Scheres worked as a
Postdoctoral researcher at the
Spanish National Center for Biotechnology (CNB) with José Maria Carazo from 2003-2010, where he developed classification algorithms for
Cryogenic electron microscopy (cryo-EM) images based on
Maximum likelihood estimation .
[4] In 2010 Scheres was appointed as a group leader at the
MRC Laboratory of Molecular Biology , Cambridge. There, he extended his maximum-likelihood methods to a general
Empirical Bayes method for
Protein structure determination by cryo-EM,
[5] which he implemented in the computer program RELION.
[6] In 2020, Scheres and collaborators used RELION to reach atomic resolution for a cryo-EM reconstruction of apo-
Ferritin .
[7]
Besides developing algorithms for cryo-EM image processing, Scheres has also collaborated with experimental groups to solve important protein structures. For example, Xiaochen Bai, currently at
UTSW , in his group solved the structure of human
Gamma secretase
[8] in a collaboration with
Shi Yigong . Since 2016, Scheres has worked closely together with
Michel Goedert , who is also at the
MRC Laboratory of Molecular Biology . Using cryo-EM image processing methods that were developed by Scheres, they solved the structure of
Amyloid fibrils of
Tau protein from the brain of an individual with
Alzheimer's disease .
[9] Since then, Scheres and Goedert have also solved the cryo-EM structures of tau filaments from multiple other
Tauopathies ,
[10] as well as filaments of
Amyloid beta from
Alzheimer's disease ,
[11]
Alpha-synuclein from
Multiple system atrophy
[12] and
TMEM106B .
[13]
Scheres has been a member of the Board of Reviewing Editors for
eLife since 2014.
[14] He has been joint Head of the Division of Structural Studies of the
MRC Laboratory of Molecular Biology since 2018.
[15] In 2021, he was elected a
Fellow of the Royal Society .
[16] In 2022, he was elected a foreign member of the
Royal Netherlands Academy of Arts and Sciences .
[17]
Awards
References
^
"Sjors Scheres - Google Scholar Citations" . scholar.google.com . Retrieved 2018-07-31 .
^
"Sjors Scheres - MRC Laboratory of Molecular Biology" . MRC Laboratory of Molecular Biology . Retrieved 2018-07-31 .
^ Scheres SH (2003).
Conditional Optimization: An N-particle formalism for protein structure refinement (Thesis).
^ Scheres SH, Gao H, Valle M, Herman GT, Eggermont PP, Frank J, Carazo JM (2007). "Disentangling Conformational States of Macromolecules in 3D-EM through Likelihood Optimization". Nature Methods . 4 (1): 27–29.
doi :
10.1038/nmeth992 .
PMID
17179934 .
S2CID
20967953 .
^ Scheres SH (2012).
"A Bayesian view on cryo-EM structure determination" . J. Mol. Biol . 415 (2): 406–18.
doi :
10.1016/j.jmb.2011.11.010 .
PMC
3314964 .
PMID
22100448 .
^ Scheres SH (2012).
"RELION: implementation of a Bayesian approach to cryo-EM structure determination" . J. Struct. Biol . 180 (3): 519–30.
doi :
10.1016/j.jsb.2012.09.006 .
PMC
3690530 .
PMID
23000701 .
^ Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PM, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchanski T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SH (2020).
"Single-particle cryo-EM at atomic resolution" . Nature . 587 (7832): 152–156.
Bibcode :
2020Natur.587..152N .
doi :
10.1038/s41586-020-2829-0 .
PMC
7611073 .
PMID
33087931 .
^ Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y (2015).
"An atomic structure of human gamma-secretase" . Nature . 525 (7568): 212–17.
Bibcode :
2015Natur.525..212B .
doi :
10.1038/nature14892 .
PMC
4568306 .
PMID
26280335 .
^ Fitzpatrick AW, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SH (2017).
"Cryo-EM structures of tau filaments from Alzheimer's disease" . Nature . 547 (7662): 185–90.
Bibcode :
2017Natur.547..185F .
doi :
10.1038/nature23002 .
PMC
5552202 .
PMID
28678775 .
^ Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DM, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SH (2021).
"Structure-based classification of tauopathies" . Nature . 598 (7880): 359–363.
Bibcode :
2021Natur.598..359S .
doi :
10.1038/s41586-021-03911-7 .
PMC
7611841 .
PMID
34588692 .
^ Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SH, Goedert M (2022).
"Cryo-EM Structures of Amyloid-beta 42 Filaments from Human Brain" . Science . 375 (6577): 167–172.
Bibcode :
2022Sci...375..167Y .
doi :
10.1126/science.abm7285 .
PMC
7612234 .
PMID
35025654 .
^ Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SH, Goedert M (2020).
"Structures of alpha-synuclein filaments from multiple system atrophy" . Nature . 585 (7825): 464–469.
Bibcode :
2020Natur.585..464S .
doi :
10.1038/s41586-020-2317-6 .
PMC
7116528 .
PMID
32461689 .
^ Schweighauser M, Arseni D, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Falcon B, Murzin AG, Goedert M, Scheres SH (2022).
"Age-dependent formation of TMEM106B amyloid filaments in human brain" . Nature . 605 (7909): 310–314.
Bibcode :
2022Natur.605..310S .
doi :
10.1038/s41586-022-04650-z .
PMC
9095482 .
PMID
35344985 .
^
"Editors for Structural Biology and Molecular Biophysics" . eLife . Retrieved 2018-07-31 .
^
"Structural Studies - MRC Laboratory of Molecular Biolog" . mrc-lmb.cam.ac.uk . Retrieved 2022-04-15 .
^
"Sjors Scheres | Royal Society" . royalsociety.org . Retrieved 2021-05-16 .
^
"Sjors Scheres" (in Dutch). Royal Netherlands Academy of Arts and Sciences. Retrieved 10 December 2023 .
^
"Sjors Scheres is awarded the Bijvoet Medal - MRC Laboratory of Molecular Biology" . MRC Laboratory of Molecular Biology . 2018-04-27. Retrieved 2018-07-31 .
^
"Sjors Scheres elected to EMBO membership - MRC Laboratory of Molecular Biology" . MRC Laboratory of Molecular Biology . 2017-06-16. Retrieved 2018-07-31 .
^
"Winners KNCV Gouden Medaille - KNCV English" . en.kncv.nl . Retrieved 2018-07-31 .
^ Callaway E (2014).
"365 days: Nature's 10" . Nature . 516 (7531): 311–19.
Bibcode :
2014Natur.516..311. .
doi :
10.1038/516311a .
PMID
25519114 .
International National Academics