Siglo XXI (Spanish for 21st century) may refer to:

• Diario Siglo XXI, a newspaper from the Valencian Community
• Siglo Veintiuno, a Guatemalan newspaper
• Siglo XXI, former name of the Argentine newspaper El Siglo, published in Tucumán
• Siglo XXI (publisher), a Spanish-language book publisher with business presences in Spain, Argentina, and Mexico

• Auditorio Siglo XXI, in Puebla, Mexico
• Siglo XXI Convention Centre, in Mérida, Yucatán, Mexico
• Siglo XXI (Madrid Metro), a station on Line ML-3

• 21st century (disambiguation)

This disambiguation page lists articles associated with the title Siglo XXI.
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