Schiller–Duval body is a cellular structure seen by
microscope in
endodermal sinus tumors (yolk sac tumors) which are the most common testicular cancer in children. Schiller-Duval bodies are present in approximately 50% of these tumors, and if found are
pathognomonic.[1] They are named for
Mathias-Marie Duval and
Walter Schiller[2] who described them in the late nineteenth century.[3]
Histopathology of endodermal sinus tumor with Schiller–Duval bodies. (a) papillary pattern combined with small tubopapillary endodermal sinus structure (Schiller–Duval body) in blue circle; (b) marked tubulopapillary sinusoidal structure with central vascular core in longitudinal section (Schiller–Duval body); (c,d) 400× g magnified image plus zoom of diagnostic round cystic Schiller–Duval body in a transverse section, with microcystic and papillary patterns around. The body has a central vessel surrounded by fibrous tissue, called the fibrovascular core, and it is surrounded by layers of the tumoral cells at the surface of that stalk. The structure is located in open cystic space also lined by tumoral cells. All those structures together are called a Schiller–Duval body and resemble primitive glomerulus. H&E stain.[5]
^Duval M. Le placenta des rongeurs. Journal de l'anatomie et de la physiologie normales et pathologiques de l'homme et des animaux, Paris, 1891, 27: 24–73, 344–395, 513–612.