Because of the unusual chemical structure and its potential biological activity, there has been research aimed at its
total synthesis.[3][4][5][6][7]
References
^Mossa, Jaber S.; Cassady, John M.; Antoun, Mikhail D.; Byrn, Stephen R.; McKenzie, Ann T.; Kozlowski, John F.; Main, P. (1985). "Saudin, a hypoglycemic diterpenoid, with a novel 6,7-seco-labdane carbon skeleton, from Cluytia richardiana". The Journal of Organic Chemistry. 50 (6): 916–918.
doi:
10.1021/jo00206a050.
^Mossa, J. S.; El-Denshary, E. S. M.; Hindawi, R.; Ageel, A. M. (1988). "The Hypoglycaemic Effect of Saudin". International Journal of Crude Drug Research. 26 (2): 81–87.
doi:
10.3109/13880208809053897.
^Labadie, Guillermo R.; Cravero, Raquel M.; González-Sierra, Manuel (1996). "Studies Toward the Total Synthesis of Saudine : Simple and Stereoselective Synthesis of a Model Caged Ketal Backbone". Synthetic Communications. 26 (24): 4671–4684.
doi:
10.1080/00397919608004793.
^Boeckman, Robert K.; Del Rosario Rico Ferreira, Maria; Mitchell, Lorna H.; Shao, Pengcheng (2002). "An Enantioselective Total Synthesis of (+)- and (−)-Saudin. Determination of the Absolute Configuration". Journal of the American Chemical Society. 124 (2): 190–191.
doi:
10.1021/ja017194i.
PMID11782168.