Sorting nexin family member 27, also known as SNX27, is a
humangene.[5]
This gene encodes a member of the
sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a
phosphoinositide binding domain (
PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the
serotonin 5-hydroxytryptamine 4 receptor into early
endosomes, suggesting the analogous role for the human protein.[5]
MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53.
doi:
10.1016/j.bbrc.2007.05.162.
PMID17577583.