From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Small nuclear ribonucleoprotein-associated proteins B and B' is a
protein that in humans is encoded by the SNRPB
gene .
[5]
[6]
Function
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.
[6]
Interactions
SNRPB has been shown to
interact with
DDX20
[7] and
Coilin .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000125835 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000027404 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Griffith AJ, Schmauss C, Craft J (July 1992). "The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site". Gene . 114 (2): 195–201.
doi :
10.1016/0378-1119(92)90574-9 .
PMID
1376292 .
^
a
b
"Entrez Gene: SNRPB small nuclear ribonucleoprotein polypeptides B and B1" .
^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999).
"Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . J. Cell Biol . 147 (6): 1181–94.
doi :
10.1083/jcb.147.6.1181 .
PMC
2168095 .
PMID
10601333 .
^ Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001).
"Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein" . Genes Dev . 15 (20): 2720–9.
doi :
10.1101/gad.908401 .
PMC
312817 .
PMID
11641277 .
Further reading
Will CL, Lührmann R (2001). "Spliceosomal UsnRNP biogenesis, structure and function". Curr. Opin. Cell Biol . 13 (3): 290–301.
doi :
10.1016/S0955-0674(00)00211-8 .
hdl :
11858/00-001M-0000-0012-F770-0 .
PMID
11343899 .
Schmauss C, Lerner MR (1990).
"The closely related small nuclear ribonucleoprotein polypeptides N and B/B' are distinguishable by antibodies as well as by differences in their mRNAs and gene structures" . J. Biol. Chem . 265 (18): 10733–9.
doi :
10.1016/S0021-9258(18)87008-9 .
PMID
1693924 .
Elkon KB, Hines JJ, Chu JL, Parnassa A (1990).
"Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction" . J. Immunol . 145 (2): 636–43.
doi :
10.4049/jimmunol.145.2.636 .
PMID
1694885 .
Chu JL, Elkon KB (1991). "The small nuclear ribonucleoproteins, SmB and B', are products of a single gene". Gene . 97 (2): 311–2.
doi :
10.1016/0378-1119(91)90069-N .
PMID
1825643 .
Sharpe NG, Williams DG, Latchman DS (1990).
"Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation" . Mol. Cell. Biol . 10 (12): 6817–20.
doi :
10.1128/mcb.10.12.6817 .
PMC
362965 .
PMID
2174118 .
Schmauss C, McAllister G, Ohosone Y, Hardin JA, Lerner MR (1989).
"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B' " . Nucleic Acids Res . 17 (4): 1733–43.
doi :
10.1093/nar/17.4.1733 .
PMC
331831 .
PMID
2522186 .
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989).
"Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles" . J. Biol. Chem . 264 (10): 5776–83.
doi :
10.1016/S0021-9258(18)83617-1 .
PMID
2522439 .
Ohosone Y, Mimori T, Griffith A, Akizuki M, Homma M, Craft J, Hardin JA (1989).
"Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles" . Proc. Natl. Acad. Sci. U.S.A . 86 (11): 4249–53.
Bibcode :
1989PNAS...86.4249O .
doi :
10.1073/pnas.86.11.4249 .
PMC
287428 .
PMID
2524838 .
van Dam A, Winkel I, Zijlstra-Baalbergen J, Smeenk R, Cuypers HT (1989).
"Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part" . EMBO J . 8 (12): 3853–60.
doi :
10.1002/j.1460-2075.1989.tb08563.x .
PMC
402073 .
PMID
2531083 .
Huntriss JD, Latchman DS, Williams DG (1993).
"Lupus autoantibodies discriminate between the highly homologous Sm polypeptides B/B' and SmN by binding an epitope restricted to B/B' " . Clin. Exp. Immunol . 92 (2): 263–7.
doi :
10.1111/j.1365-2249.1993.tb03390.x .
PMC
1554819 .
PMID
7683587 .
Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS (1993). "The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein". J. Mol. Cell. Cardiol . 25 (3): 321–9.
doi :
10.1006/jmcc.1993.1038 .
PMID
8510173 .
Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V (1997).
"PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb" . Oncogene . 14 (2): 145–55.
doi :
10.1038/sj.onc.1200825 .
PMID
9010216 .
Liu Q, Fischer U, Wang F, Dreyfuss G (1997).
"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013–21.
doi :
10.1016/S0092-8674(00)80367-0 .
PMID
9323129 .
S2CID
10855404 .
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res . 237 (1): 63–9.
doi :
10.1006/excr.1997.3750 .
PMID
9417867 .
Bedford MT, Reed R, Leder P (1998).
"WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif" . Proc. Natl. Acad. Sci. U.S.A . 95 (18): 10602–7.
Bibcode :
1998PNAS...9510602B .
doi :
10.1073/pnas.95.18.10602 .
PMC
27941 .
PMID
9724750 .
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999).
"Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs" . Cell . 96 (3): 375–87.
doi :
10.1016/S0092-8674(00)80550-4 .
PMID
10025403 .
S2CID
17379935 .
Gray TA, Smithwick MJ, Schaldach MA, Martone DL, Graves JA, McCarrey JR, Nicholls RD (1999).
"Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci" . Nucleic Acids Res . 27 (23): 4577–84.
doi :
10.1093/nar/27.23.4577 .
PMC
148745 .
PMID
10556313 .
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (1999).
"Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . J. Cell Biol . 147 (6): 1181–94.
doi :
10.1083/jcb.147.6.1181 .
PMC
2168095 .
PMID
10601333 .
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000).
"Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli" . J. Cell Biol . 148 (6): 1177–86.
doi :
10.1083/jcb.148.6.1177 .
PMC
2174312 .
PMID
10725331 .