From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Splicing factor 3B subunit 3 is a
protein that in humans is encoded by the SF3B3
gene .
[5]
[6]
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
[6]
Interactions
SF3B3 has been shown to
interact with
SF3B1 ,
[5]
[7]
Transcription initiation protein SPT3 homolog
[8] and
TAF9 .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000189091 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000033732 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000).
"Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155" . Mol Cell Biol . 19 (10): 6796–802.
doi :
10.1128/mcb.19.10.6796 .
PMC
84676 .
PMID
10490618 .
^
a
b
"Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa" .
^ Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002).
"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . EMBO J . 21 (18): 4978–88.
doi :
10.1093/emboj/cdf480 .
ISSN
0261-4189 .
PMC
126279 .
PMID
12234937 .
^
a
b Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001).
"Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo" . Mol. Cell. Biol . 21 (20): 6782–95.
doi :
10.1128/MCB.21.20.6782-6795.2001 .
ISSN
0270-7306 .
PMC
99856 .
PMID
11564863 .
Further reading
Nomura N, Miyajima N, Sazuka T, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35.
doi :
10.1093/dnares/1.1.27 .
PMID
7584026 .
Nomura N, Miyajima N, Sazuka T, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)" . DNA Res . 1 (1): 47–56.
doi :
10.1093/dnares/1.1.47 .
PMID
7584028 .
Bonaldo MF; Lennon G; Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Mintz PJ, Patterson SD, Neuwald AF, et al. (1999).
"Purification and biochemical characterization of interchromatin granule clusters" . EMBO J . 18 (15): 4308–20.
doi :
10.1093/emboj/18.15.4308 .
PMC
1171507 .
PMID
10428969 .
Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001).
"UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation" . EMBO J . 20 (12): 3187–96.
doi :
10.1093/emboj/20.12.3187 .
PMC
150203 .
PMID
11406595 .
Gangloff YG, Pointud JC, Thuault S, et al. (2001).
"The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger" . Mol. Cell. Biol . 21 (15): 5109–21.
doi :
10.1128/MCB.21.15.5109-5121.2001 .
PMC
87236 .
PMID
11438666 .
Will CL, Schneider C, MacMillan AM, et al. (2001).
"A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site" . EMBO J . 20 (16): 4536–46.
doi :
10.1093/emboj/20.16.4536 .
PMC
125580 .
PMID
11500380 .
Martinez E, Palhan VB, Tjernberg A, et al. (2001).
"Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo" . Mol. Cell. Biol . 21 (20): 6782–95.
doi :
10.1128/MCB.21.20.6782-6795.2001 .
PMC
99856 .
PMID
11564863 .
Jurica MS, Licklider LJ, Gygi SR, et al. (2002).
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39.
doi :
10.1017/S1355838202021088 .
PMC
1370266 .
PMID
11991638 .
Scott MP, Zappacosta F, Kim EY, et al. (2002).
"Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1" . J. Biol. Chem . 277 (31): 28238–46.
doi :
10.1074/jbc.M202783200 .
PMID
12029088 .
Will CL, Urlaub H, Achsel T, et al. (2002).
"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein" . EMBO J . 21 (18): 4978–88.
doi :
10.1093/emboj/cdf480 .
PMC
126279 .
PMID
12234937 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Cavusoglu N; Brand M; Tora L; Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics . 3 (2): 217–23.
doi :
10.1002/pmic.200390030 .
PMID
12601814 .
S2CID
6035986 .
Li J, Hawkins IC, Harvey CD, et al. (2003).
"Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins" . Mol. Cell. Biol . 23 (21): 7437–47.
doi :
10.1128/MCB.23.21.7437-7447.2003 .
PMC
207616 .
PMID
14559993 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Will CL, Schneider C, Hossbach M, et al. (2004).
"The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome" . RNA . 10 (6): 929–41.
doi :
10.1261/rna.7320604 .
PMC
1370585 .
PMID
15146077 .
Jin J, Smith FD, Stark C, et al. (2004).
"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Curr. Biol . 14 (16): 1436–50.
doi :
10.1016/j.cub.2004.07.051 .
PMID
15324660 .
S2CID
2371325 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein–protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .