From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Methionine-R-sulfoxide reductase B1 is an
enzyme that in humans is encoded by the SEPX1
gene .
[5]
[6]
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the
methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.
[6]
See also
References
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Kryukov GV, Kryukov VM, Gladyshev VN (1999).
"New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements" . J. Biol. Chem . 274 (48): 33888–97.
doi :
10.1074/jbc.274.48.33888 .
PMID
10567350 .
Zhang QH, Ye M, Wu XY, et al. (2001).
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60.
doi :
10.1101/gr.140200 .
PMC
310934 .
PMID
11042152 .
Daniels RJ, Peden JF, Lloyd C, et al. (2001).
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16" . Hum. Mol. Genet . 10 (4): 339–52.
doi :
10.1093/hmg/10.4.339 .
PMID
11157797 .
Moskovitz J, Singh VK, Requena J, et al. (2002).
"Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity" . Biochem. Biophys. Res. Commun . 290 (1): 62–5.
doi :
10.1006/bbrc.2001.6171 .
PMID
11779133 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Kim HY, Gladyshev VN (2004).
"Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases" . Mol. Biol. Cell . 15 (3): 1055–64.
doi :
10.1091/mbc.E03-08-0629 .
PMC
363075 .
PMID
14699060 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .