In patients with amyloidosis, large deposits of SAP coat the affected organs, in addition to the low levels normally found in the blood stream.[3] The injected 123I-SAP localises specifically to amyloid deposits, showing up as hot spots in the image.[4]
Procedure
The
radiopharmaceutical is injected into the patient, with imaging taking place on a gamma camera 6-24 hours later.[3] An early blood-pool image provides a baseline for comparison with the organ SAP uptake after 24 hours.[4]
^
abNoordzij, Walter; Glaudemans, Andor W. J. M.; Slart, Riemer H. J. A.; Dierckx, Rudi A.; Hazenberg, Bouke P. C. (22 August 2012). "Clinical use of differential nuclear medicine modalities in patients with ATTR amyloidosis". Amyloid. 19 (4): 208–211.
doi:
10.3109/13506129.2012.717993.
PMID17504868.