From Wikipedia, the free encyclopedia
S-14,506
Names
Preferred IUPAC name
4-Fluoro-N -{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide
Identifiers
ChEBI
ChemSpider
UNII
InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
Key: IFMQODYDAUKKEN-UHFFFAOYSA-N
InChI=1/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
Key: IFMQODYDAUKKEN-UHFFFAOYAH
COC1=CC2=C(C=CC=C2N3CCN(CC3)CCNC(=O)C4=CC=C(C=C4)F)C=C1
Properties
C 24 H 26 F N 3 O 2
Molar mass
407.489 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
S-14,506 is a
naphthylpiperazine , a
5-HT1A receptor agonist,
[1] and a
dopamine receptor antagonist.
[2]
References
^ Milligan, G.; Kellett, E.; Dacquet, C.; Dubreuil, V.; Jacoby, E.; Millan, M. J.; Lavielle, G.; Spedding, M. (2001). "S 14506: Novel receptor coupling at 5-HT(1A) receptors". Neuropharmacology . 40 (3): 334–344.
doi :
10.1016/s0028-3908(00)00162-3 .
PMID
11166326 .
S2CID
36060096 .
^ Protais, P.; Chagraoui, A.; Arbaoui, J.; Mocaër, E. (1994). "Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents". European Journal of Pharmacology . 271 (1): 167–177.
doi :
10.1016/0014-2999(94)90277-1 .
PMID
7698199 .