Rugulovasines are bio-active
alkaloids made by Penicillium.[1] Rugulovasine A and B bind strongly to the
5-HT1A,
5-HT2A, and
5-HT2C receptors, but lack meaningful binding affinity towards the
α1 adrenergic and
dopamine receptors.[2] Little is known about the in vivo activity of Rugulovasine A and B, although they have hypotensive effects in cats.[3]
^Nagaoka, A; Kikuchi, K (January 1972). "Pharmacological studies of new indole alkaloids, rugulovasine A and B hydrochloride. II. Hypotensive mechanism of both alkaloids in the anesthetized cats". Arzneimittel-Forschung. 22 (1): 143–6.
PMID5066989.