From Wikipedia, the free encyclopedia
In
genetics , rs1800955 (also written as C-521T and -521C/T ) is a
single nucleotide polymorphism (SNP).
It is located in the
promoter region of the
DRD4 gene.
This gene codes for the
dopamine receptor D4.
Due to the
dopamine hypothesis of schizophrenia the SNP has been investigated for link to
schizophrenia , and it may be slightly associated with this disorder.
[1]
The SNP has been investigated with respect to
novelty seeking , — a
personality trait that may be measured with the
Temperament and Character Inventory .
[2]
[3]
A 2008
meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.
[4]
References
^
"Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955" .
Schizophrenia Research Forum . Retrieved 2008-09-05 . [
permanent dead link ]
^
Y. Okuyama ,
H. Ishiguro ,
M. Nankai ,
H. Shibuya ,
A. Watanabe &
T. Arinami (January 2000).
"Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait" .
Molecular Psychiatry . 5 (1): 64–69.
doi :
10.1038/sj.mp.4000563 .
PMID
10673770 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
^
Z. Ronai ,
A. Szekely ,
Z. Nemoda ,
K. Lakatos ,
J. Gervai ,
M. Staub &
M. Sasvari-Szekely (January 2001).
"Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene" .
Molecular Psychiatry . 6 (1): 35–38.
doi :
10.1038/sj.mp.4000832 .
PMID
11244482 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
^
Marcus R. Munafo ,
Binnaz Yalcin ,
Saffron A. Willis-Owen &
Jonathan Flint (January 2008). "Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data".
Biological Psychiatry . 63 (2): 197–206.
doi :
10.1016/j.biopsych.2007.04.006 .
PMID
17574217 .
S2CID
28997438 . {{
cite journal }}
: CS1 maint: multiple names: authors list (
link )
Other
Table 4 from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"