From Wikipedia, the free encyclopedia
Chemical reaction
Rieche formylation is a type of
formylation reaction. The substrates are electron rich
aromatic compounds, such as
mesitylene
[1] or
phenols,
[2] with
dichloromethyl methyl ether acting as the formyl source. The
catalyst is
titanium tetrachloride and the workup is acidic. The reaction is named after
Alfred Rieche who discovered it in 1960.
[3]
See also
Reimer–Tiemann reaction.
References
-
^ Rieche, A.; Gross, H.; Höft, E. (1967). "Aromatic Aldehydes. Mesitaldehyde".
Organic Syntheses. 47 (47): 1.
doi:
10.15227/orgsyn.047.0001.
-
^ García, Oscar; Nicolás, Ernesto; Albericio, Fernando (June 2003). "o-Formylation of electron-rich phenols with dichloromethyl methyl ether and TiCl4".
Tetrahedron Letters. 44 (27): 4961–4963.
doi:
10.1016/S0040-4039(03)01168-7.
-
^ Rieche, Alfred; Gross, Hans; Höft, Eugen (January 1960). "Über α-Halogenäther, IV. Synthesen aromatischer Aldehyde mit Dichlormethyl-alkyläthern".
Chemische Berichte. 93 (1): 88–94.
doi:
10.1002/cber.19600930115.