Richard I. Morimoto is a
Japanese American molecular biologist. He is the Bill and Gayle Cook Professor of Biology and Director of the Rice Institute for Biomedical Research at
Northwestern University .
[1]
Education and academic career
He holds a B.S. from the
University of Illinois at Chicago , received a Ph.D. in biology (laboratory of Professor Murray Rabinowitz) from The
University of Chicago in 1978, and conducted postdoctoral research (laboratory of Professor
Matthew Meselson )
[2] and was a Tutor in Biochemical Sciences at
Harvard University in Cambridge, MA. In 1982, Morimoto joined the faculty of the Department of Biochemistry, Molecular Biology, and Cell Biology at
Northwestern University in Evanston, IL. He served previously as the Chair of Biochemistry, Molecular Biology, and Cell Biology, the Dean of The Graduate School, and the Associate Provost of Graduate Education at
Northwestern University .
Civic leadership
Faculty liaison to founding of the Asian American Studies Program at [[Northwestern University
[3] ]] – March, 1995
Faculty Advisory Board – Asian American Studies Program at
Northwestern University – 1999-
Midwest Buddhist Temple , Chicago, IL. – Board of Trustees, 2004- ; President, Board of Trustees, 2009 – 2014
Japanese American Citizens League , Japanese American of the Biennium, 2010
Chicago Nikkei Forum , 2014-
Board of Trustees,
Japanese American National Museum , 2014-
Japanese American Leadership Delegation, 2015 ,
U.S.-Japan Council (USJC), Foreign Ministry of Japan
Science
Morimoto is widely recognized for his research on the regulation of the
heat shock stress response and the function of
molecular chaperones .
[4] His current research is to understand how organisms sense and respond to physiologic and environmental stress through the activation of genetic pathways that integrate stress responses with molecular and cellular responses that determine cell growth and cell death. The stress of misfolded and damaged proteins influences neuronal function and lifespan at the level of the organism. Consequently, these studies provide a molecular basis to elucidate the underlying mechanisms of neurodegenerative diseases including
Huntington's disease ,
Parkinson's disease , ALS, and
Alzheimer's disease . His laboratory has published over 250 papers and three monographs including two books on the Heat Shock Response and Molecular Chaperones from Cold Spring Harbor Press. During that period he received two MERIT awards from the
National Institutes of Health and has been supported by the grants from the National Institutes for General Medical Science, National Institutes of Aging, National Institutes for Neurological Diseases and Stroke,
American Cancer Society ,
Huntington's Disease Society of America , the Hereditary Disease Foundation, and the ALS Association. In addition to giving frequent talks at universities and scientific symposia throughout the world, he has been a visiting professor at the
Technion University in Israel,
Osaka University ,
Kyoto University ,
Kyoto Sangyo University ,
University of Rome ,
Beijing University ,
Åbo Akademi University in Finland, and
École Normale Supérieure in Paris. He is a founder of
Proteostasis Therapeutics, Inc. in Cambridge, MA, a biotech company that is discovering and developing novel small molecule therapeutics designed to control the body's protein homeostasis. These novel therapies are designed to treat multiple degenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer, and type II diabetes.
Science recognition
American Cancer Society Faculty Research Award, 1987
Commandeur, Ordre des Palmes Académiques, Ministry of Education, France, 2013
[5]
Doctor of Philosophy, Honoris Causa – Abo Akademi University, Turku, Finland, 2008
Dreyfus Distinguished Young Faculty Award, 1982
Elected Fellow of the
American Academy of Arts and Sciences , 2011
Elected Fellow of the
American Association for the Advancement of Science , 1998
Feodor Lynen Medal , 2014
National Institutes of Health Merit Award - National Institute for General Medical Science (2000), National Institute on Aging (2011)
Huntington's Disease Society of America, Award for Excellence in Medicine, 2005
Japan Society for the Promotion of Science Fellow, 2015
University of Illinois, Alumni Achievement Award, 2011
Significant papers
Capano, L. S., C. Sato, E. Ficulle, A. Yu, K. Horie, N. R. Barthelemy, S. G. Fox, C. M. Karch, R. J. Bateman, H. Houlden, R. I. Morimoto, D. M. Holtzman, K. E. Duff, and A. S. Yoo. Recapitulation of Endogenous 4R Tau Expression Analogous to the Adult Brain in Directly Reprogrammed Human Neurons. Cell Stem Cell. 29: 918–932, doi: 10.1016/j.stem.2022.04.018 (2022).
Morimoto, R.I., and G.S. Budinger. Protein Folding Disorders. In: Harrison's Principles of Internal Medicine (eds. J. Loscalzo, A. Fauci, D.L. Kasper, S.L. Hauser, D.L. Longo, J.L. Jameson), 21, Ch. 491 (2022).
Sala, A.J. and R.I. Morimoto. Protecting the Future: Balancing Proteostasis for Reproduction. Trends in Cell Biology. 32(3): 202–215, doi.org/10.1016/j.tcb.2021.09.009 (2022).
Sinnige, T., G. Meisl, T. C. T. Michaels, M. Vendruscolo, T. P.J. Knowles, and R. I. Morimoto. Kinetic Analysis Reveals that Independent Nucleation Events Determines the Progression of Protein Aggregation in C. elegans. Proc. Natl. Acad. Sci. U.S.A. 118(11):
https://doi.org/10.1073/pnas.2021888118 (2021).
Sala, A.J., L.C. Bott, R.M. Brielmann, and R.I. Morimoto.
Embryo Integrity Regulates Maternal Proteostasis and Stress Resilience . Genes and Development. 34: 678–687,doi:10.1101/gad.335422.119, PMID 32217667 (2020).
Morimoto, R.I.
Cell Non-Autonomous Regulation of Proteostasis in Aging and Disease. Cold Spring Harbor Perspectives in Biology DOI: 10.1101/cshperspect.a034074 (2019).
Morimoto, R.I.
Cell Non-Autonomous Regulation of Proteostasis in Aging and Disease. Protein Homeostasis in Biology and Disease , eds. R.I. Morimoto, F. U. Hartl and J. W. Kelly, Cold Spring Harbor Press, 552p. (2019).
Yu, A., S.G. Fox, A. Cavallini, C. Kerridge, M. J. O'Neill, J. Wolak, S. Bose, and R. I. Morimoto.
Tau Protein Aggregates Inhibit the Protein-Folding and Vesicular Trafficking Arms of the Cellular Proteostasis Network . J. Biological Chemistry 294(19): 7917-7930 DOI:10.1074/jbc.RA119.007527 (2019).
Stoeger, T., M. Gerlach, R.I. Morimoto, and L.N. Amaral.
Large Scale Investigation of the Reasons why Potentially Important Genes are Ignored . PLoS Biology 16(9): e2006643 DOI.org/10/1371/journal.pbio.2006643 (2018).
Ciryam, P., I. Lambert-Smith, D. M. Bean,D. N. Saunders, M. R. Wilson, R. I. Morimoto, S. G. Oliver, C. M. Dobson, M. Vendruscolo, G. Favrin, and J. J. Yerbury.
Tissue-specific Patterns of Supersaturation are Associated with Co-Aggregation in ALS Inclusion Bodies . Proc. Natl. Acad. Sci. USA. 114(20): E3935–E3943 DOI:10.1073/pnas.1613854114 (2017).
Sala, A.J., L.C. Bott, and R.I. Morimoto.
Shaping Proteostasis at the Cellular, Tissue, and Organismal Level . Journal of Cell Biology 216: DOI: 10.1083/jcb.201612111 (2017).
Kundra, R., P. Ciryam, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo.
Protein Homeostasis of a Metastable Subproteome Associated with Alzheimer's Disease . Proc. Natl. Acad. Sci. USA. 114(28): E5703-E5711 DOI: 10.1073/pnas.1618417114 (2017).
Li, J., J. Labbadia, and R.I. Morimoto.
Rethinking the Roles of HSF-1 in Cell Stress, Development and Organismal Health . Trends in Cell Biology 12: DOI: org/10.1016/ j.tcb.2017.08.002 (2017).
Kirstein, J., K. Arnsburg, A. Scior, A. Szlachcic, D. Lys Guilbride, R.I. Morimoto, B. Bukau, and N.B. Nillegoda.
In vivo Properties of the Disaggregase Function of J-domain Proteins and Hsc70 in C. elegans Stress and Aging . Aging Cell 16: 1414–1424, DOI: 10.1111/acel.12686 (2017).
Labbadia, J., R. Brielmann, M. Neto, Y.-F. Lin, C.M. Haynes, and R.I. Morimoto.
Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse During Aging . Cell Reports 21: 1481–1494, DOI.org/10.1016/ j.celrep.2017.10.038 (2017).
Ciryam, P., R. Kundra, R. Freer, R. I. Morimoto, C. M. Dobson, and M. Vendruscolo.
A Transcriptional Signature of Alzheimer's Disease is Associated with a Metastable Subproteome at Risk for Aggregation . Proc. Natl. Acad. Sci. U.S.A. 113 (17): 4753-4758 DOI: 10.1073 (2016).
Li, J., L. Chauve, G. Phelps, R. Brielmann, and R.I. Morimoto.
E2F Co-regulates an Essential HSF Developmental Program Distinct from the Heat Shock Response . Genes and Development 30: 2062-2075 PMID 27688402 (2016).
Winter, P. B., R. M. Brielmann, N. P. Timkovich, H. T. Navarro, A. Teixeira-Castro, R. I. Morimoto, and L. A. N. Amaral.
A Network Approach to Discerning the Identities of Visually Indistinguishable Organisms in a Free Moving Population . Scientific Reports 6: DOI: 10.1038/srep34859 (2016).
Teixeira-Castro, A; Jalles, A; Esteves, S; Kang, S; da Silva Santos, L; Silva-Fernandes, A; Neto, MF; Brielmann, RM; Bessa, C; Duarte-Silva, S; Miranda, A; Oliveira, S; Neves-Carvalho, A; Bessa, J; Summavielle, T; Silverman, RB; Oliveira, P; Morimoto, RI; Maciel, P (2015).
"Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease" . Brain . 138 (11): 3221–37.
doi :
10.1093/brain/awv262 .
PMC
4731417 .
PMID
26373603 .
Nillegoda, NB; Kirstein, J; Szlachcic, A; Berynskyy, M; Stank, A; Stengel, F; Arnsburg, K; Gao, X; Scior, A; Aebersold, R; Guilbride, DL; Wade, RC; Morimoto, RI; Mayer, MP; Bukau, B (2015).
"Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation" . Nature . 524 (7564): 247–51.
Bibcode :
2015Natur.524..247N .
doi :
10.1038/nature14884 .
PMC
4830470 .
PMID
26245380 .
Kirstein, J; Morito, D; Kakihana, T; Sugihara, M; Minnen, A; Hipp, MS; Nussbaum-Krammer, C; Kasturi, P; Hartl, FU; Nagata, K; Morimoto, RI (2015).
"Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments" . EMBO J . 34 (18): 2334–49.
doi :
10.15252/embj.201591711 .
PMC
4570520 .
PMID
26228940 .
Labbadia, J.; Morimoto, R.I. (2015).
"Repression of the Heat Shock Response is a Programmed Event at the Onset of Reproduction" . Molecular Cell . 59 (4): 639–650.
doi :
10.1016/j.molcel.2015.06.027 .
PMC
4546525 .
PMID
26212459 .
Walther, DM; Kasturi, P; Zheng, M; Pinkert, S; Vecchi, G; Ciryam, P; Morimoto, RI; Dobson, CM; Vendruscolo, M; Mann, M; Hartl, FU (2015).
"Widespread Proteome Remodeling and Aggregation in Aging C. elegans" . Cell . 161 (4): 919–32.
doi :
10.1016/j.cell.2015.03.032 .
PMC
4643853 .
PMID
25957690 .
Labbadia, J; Morimoto, RI (2015).
"The biology of proteostasis in aging and disease" . Annu Rev Biochem . 84 : 435–64.
doi :
10.1146/annurev-biochem-060614-033955 .
PMC
4539002 .
PMID
25784053 .
Yu, MS; Kim, BH; Kang, SH; Lim, DJ (2015). "Combined use of crushed cartilage and fibrin sealant for radix augmentation in Asian rhinoplasty". Plast Reconstr Surg . 135 (2): 293e–300e.
doi :
10.1097/PRS.0000000000001114 .
PMID
25626813 .
S2CID
40582922 .
Tatum, MC; Ooi, FK; Chikka, MR; Chauve, L; Martinez-Velazquez, LA; Steinbusch, HW; Morimoto, RI; Prahlad, V (2015).
"Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase" . Curr Biol . 25 (2): 163–74.
doi :
10.1016/j.cub.2014.11.040 .
PMC
4840938 .
PMID
25557666 .
Roth, DM; Hutt, DM; Tong, J; Bouchecareilh, M; Wang, N; Seeley, T; Dekkers, JF; Beekman, JM; Garza, D; Drew, L; Masliah, E; Morimoto, RI; Balch, WE (2014).
"Modulation of the maladaptive stress response to manage diseases of protein folding" . PLOS Biol . 12 (11): e1001998.
doi :
10.1371/journal.pbio.1001998 .
PMC
4236052 .
PMID
25406061 .
Kennedy, BK; Berger, SL; Brunet, A; Campisi, J; Cuervo, AM; Epel, ES; Franceschi, C; Lithgow, GJ; Morimoto, RI; Pessin, JE; Rando, TA; Richardson, A; Schadt, EE; Wyss-Coray, T; Sierra, F (2014).
"Geroscience: linking aging to chronic disease" . Cell . 159 (4): 709–13.
doi :
10.1016/j.cell.2014.10.039 .
PMC
4852871 .
PMID
25417146 .
Brehme, M; Voisine, C; Rolland, T; Wachi, S; Soper, JH; Zhu, Y; Orton, K; Villella, A; Garza, D; Vidal, M; Ge, H; Morimoto, RI (2014).
"A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease" . Cell Rep . 9 (3): 1135–50.
doi :
10.1016/j.celrep.2014.09.042 .
PMC
4255334 .
PMID
25437566 .
van Oosten-Hawle, P; Morimoto, RI (2014).
"Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling" . Genes Dev . 28 (14): 1533–43.
doi :
10.1101/gad.241125.114 .
PMC
4102760 .
PMID
25030693 .
Shibata, Y; Morimoto, RI (2014).
"How the nucleus copes with proteotoxic stress" . Curr Biol . 24 (10): R463-74.
doi :
10.1016/j.cub.2014.03.033 .
PMC
4207067 .
PMID
24845679 .
Yu, A; Shibata, Y; Shah, B; Calamini, B; Lo, DC; Morimoto, RI (2014).
"Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition" . Proc Natl Acad Sci U S A . 111 (15): E1481-90.
Bibcode :
2014PNAS..111E1481Y .
doi :
10.1073/pnas.1321811111 .
PMC
3992642 .
PMID
24706768 .
Ciryam, P.; Tartaglia, G. G.; Morimoto, R. I.; Dobson, C. M.; Vendruscolo, M. (2013).
"Neurodegenerative Diseases and Widespread Aggregation are Associated with Supersaturated Proteins" . Cell Reports . 5 (3): 781–790.
doi :
10.1016/j.celrep.2013.09.043 .
PMC
3883113 .
PMID
24183671 .
Gidalevitz, G.; Wang, N.; Deravaj, T.; Morimoto, R.I. (2013).
"Natural Genetic Variation Determines Susceptibility to Aggregation or Toxicity in a C. elegans model for Polyglutamine Disease" . BMC Biology . 11 : 100.
doi :
10.1186/1741-7007-11-100 .
PMC
3816611 .
PMID
24079614 .
Silva, M. C.; Amaral, M. D.; Morimoto, R.I. (2013).
"Neuronal Reprogramming of Protein Homeostasis by Calcium-Dependent Regulation of the Heat Shock Response" . PLOS Genetics . 9 (8): e1003711.
doi :
10.1371/journal.pgen.1003711 .
PMC
3757039 .
PMID
24009518 .
Labbadia, J.; Morimoto, R.I. (2013).
"Huntington's Disease – Underlying Molecular Mechanisms and Emerging Concepts" . Trends in Biochemical Sciences . 38 (8): 378–385.
doi :
10.1016/j.tibs.2013.05.003 .
PMC
3955166 .
PMID
23768628 .
van Oosten-Hawle, P.; Porter, R.; Morimoto, R. I. (2013).
"Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling" . Cell . 153 (6): 1366–1378.
doi :
10.1016/j.cell.2013.05.015 .
PMC
3955170 .
PMID
23746847 .
Kirstein-Miles, J; Scior, A; Deuerling, E; Morimoto, RI (2013).
"The nascent polypeptide-associated complex is a key regulator of proteostasis" . EMBO J . 32 (10): 1451–68.
doi :
10.1038/emboj.2013.87 .
PMC
3655472 .
PMID
23604074 .
Guisbert, E.; Czyz, D. M.; Richter, K.; McMullen, P. D.; Morimoto, R. I. (2013).
"Identification of a Tissue-Selective Heat Shock Response Regulatory Network" . PLOS Genetics . 9 (4): e1003466.
doi :
10.1371/journal.pgen.1003466 .
PMC
3630107 .
PMID
23637632 .
Krammer, C.; Park, K.W.; Li, L.; Melki, R.; Morimoto, R.I. (2013).
"Spreading of a Prion Domain from Cell to Cell by Vesicular Transport in C. elegans" . PLOS Genetics . 9 (3): e1003351.
doi :
10.1371/journal.pgen.1003351 .
PMC
3610634 .
PMID
23555277 .
Ciryam, P; Morimoto, RI; Vendruscolo, M; Dobson, CM; O'Brien, EP (2013).
"In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome" . Proc Natl Acad Sci U S A . 110 (2): E132-40.
doi :
10.1073/pnas.1213624110 .
PMC
3545769 .
PMID
23256155 .
Rampelt, H; Kirstein-Miles, J; Nillegoda, NB; Chi, K; Scholz, SR; Morimoto, RI; Bukau, B (2012).
"Metazoan Hsp70 machines use Hsp110 to power protein disaggregation" . EMBO J . 31 (21): 4221–35.
doi :
10.1038/emboj.2012.264 .
PMC
3492728 .
PMID
22990239 .
Morimoto, RI (2011).
"The heat shock response: systems biology of proteotoxic stress in aging and disease" . Cold Spring Harb Symp Quant Biol . 76 : 91–9.
doi :
10.1101/sqb.2012.76.010637 .
PMID
22371371 .
Silva, M. C.; Fox, S.; Thakkar, H.; Beam, M. J. Rivera; Amaral, M. D.; Morimoto, R.I. (2011).
"A Genetic Screening Strategy Identifies Novel Global Regulators of the Proteostasis Network" . PLOS Genetics . 7 (12): e1002438.
doi :
10.1371/journal.pgen.1002438 .
PMC
3248563 .
PMID
22242008 .
Calamini, B.; Silva, C.; Madoux, F.; Hutt, D. M.; Khanna, S.; Chalfant, M.; Hodder, P.; Tait, B.; Garza, D.; Balch, W.; Morimoto, R.I. (2012).
"Small Molecule Proteostasis Regulators for Protein Conformational Disease" . Nature Chemical Biology . 8 (2): 185–196.
doi :
10.1038/nchembio.763 .
PMC
3262058 .
PMID
22198733 .
Teixeira-Castro, A; Ailion, M; Jalles, A; et al. (August 2011).
"Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways" . Hum. Mol. Genet . 20 (15): 2996–3009.
doi :
10.1093/hmg/ddr203 .
PMC
3131043 .
PMID
21546381 .
Prahlad, V; Morimoto, RI (2011).
"Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins" . Proc Natl Acad Sci U S A . 108 (34): 14204–9.
Bibcode :
2011PNAS..10814204P .
doi :
10.1073/pnas.1106557108 .
PMC
3161566 .
PMID
21844355 .
Gidalevitz, T; Prahlad, V; Morimoto, RI (June 2011).
"The stress of protein misfolding: from single cells to multicellular organisms" . Cold Spring Harb Perspect Biol . 3 (6): a009704.
doi :
10.1101/cshperspect.a009704 .
PMC
3098679 .
PMID
21536706 .
Åkerfelt, M.; Morimoto, R.I.; Sistonen, L. (2010).
"Heat Shock Factors: Integrators of Cell Stress, Development, and Lifespan" . Nature Reviews Molecular Cell Biology . 11 (8): 545–555.
doi :
10.1038/nrm2938 .
PMC
3402356 .
PMID
20628411 .
Ben-Zvi-A; Miller, E.A.; Morimoto, R.I. (2009).
"The Collapse of Proteostasis Represents an Early Molecular Event in C. elegans Aging" . Proc. Natl. Acad. Sci. USA . 106 (35): 14914–14919.
doi :
10.1073/pnas.0902882106 .
PMC
2736453 .
PMID
19706382 .
Powers, E.T.; Morimoto, R.I.; Dillin, A.; Kelly, J.W.; Balch, W.E. (2009). "Biological and Chemical Approaches to Diseases of Proteostasis Deficiency". Annual Review of Biochemistry . 78 : 959–991.
doi :
10.1146/annurev.biochem.052308.114844 .
PMID
19298183 .
Westerheide, S.D.; Anckar, J.; Stevens, S.; Sistonen, L.; Morimoto, R.I. (2009).
"Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1" . Science . 323 (5917): 1063–1066.
Bibcode :
2009Sci...323.1063W .
doi :
10.1126/science.1165946 .
PMC
3429349 .
PMID
19229036 .
Prahlad, V.; Cornelius, T.; Morimoto, R.I. (2008).
"Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons" . Science . 320 (5877): 811–814.
Bibcode :
2008Sci...320..811P .
doi :
10.1126/science.1156093 .
PMC
3429343 .
PMID
18467592 .
Balch, W. E.; Morimoto, R.I.; Dillin, A.; Kelly, J. W. (2008). "Adapting Proteostasis for Disease Intervention". Science . 319 (5865): 916–919.
Bibcode :
2008Sci...319..916B .
doi :
10.1126/science.1141448 .
PMID
18276881 .
S2CID
20952037 .
Morimoto, R.I. (2008).
"Proteotoxic Stress and Inducible Chaperone Networks in Neurodegenerative Disease and Aging" . Genes & Development . 22 (11): 1427–1438.
doi :
10.1101/gad.1657108 .
PMC
2732416 .
PMID
18519635 .
Garcia, S.; Casanueva, M.O.; Silva, C.; Amaral, M.; Morimoto, R.I. (2007).
"Neuronal Signaling Modulates Protein Homeostasis in Caenorhabditis elegans Postsynaptic Muscle Cells" . Genes & Development . 21 (22): 3006–3016.
doi :
10.1101/gad.1575307 .
PMC
2049200 .
PMID
18006691 .
Brignull, H.; Moore, F.; Tang, S.; Morimoto, R.I. (2006).
"Polyglutamine Proteins at the Pathogenic Threshold Display Neuron-Specific Aggregation in a Pan-Neuronal C. elegans Model" . Journal of Neuroscience . 26 (29): 7597–7606.
doi :
10.1523/jneurosci.0990-06.2006 .
PMC
6674286 .
PMID
16855087 .
Gidalevitz, T.; Ben-Zvi, A.; Ho, K.; Brignull, H.; Morimoto, R.I. (2006).
"Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases " . Science . 311 (5766): 1471–1474.
Bibcode :
2006Sci...311.1471G .
doi :
10.1126/science.1124514 .
PMID
16469881 .
S2CID
8210087 .
Holmberg, C.; Staniszewski, K.; Mensah, K.; Chavez, A.; Matouschek, A.; Morimoto, R.I. (2004).
"Inefficient Degradation of Truncated Polyglutamine Proteins by the Proteasome" . EMBO Journal . 23 (21): 4307–4318.
doi :
10.1038/sj.emboj.7600426 .
PMC
524390 .
PMID
15470501 .
Morley, J.F.; Morimoto, R.I. (2004).
"Regulation of Longevity in C. elegans by Heat Shock Factor and Molecular Chaperones" . Mol. Biol. Cell . 15 (2): 657–664.
doi :
10.1091/mbc.e03-07-0532 .
PMC
329286 .
PMID
14668486 .
Morimoto, R.I. (2002).
"Dynamic Remodeling of Transcription Complexes by Molecular Chaperones" . Cell . 110 (3): 281–284.
doi :
10.1016/s0092-8674(02)00860-7 .
PMID
12176314 .
S2CID
9013678 .
Kim, S.; Nollen, E.A.A.; Kitagawa, K.; Bindokas, V.; Morimoto, R.I. (2002). "Polyglutamine Protein Aggregates are Dynamic". Nature Cell Biology . 4 (10): 826–831.
doi :
10.1038/ncb863 .
PMID
12360295 .
S2CID
16305135 .
Morley J.F., Brignull H.R., Weyers J.J. and R.I. Morimoto. "The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. (2002). doi 10.1073/pnas.152161099
Shen, X.; Ellis, R.E.; Lee, K.; Liu, C.-Y.; Yang, K.; Solomon, A.; Yoshida, H.; Morimoto, R.; Kurnit, D.M.; Mori, K.; Kaufman, R.J. (2001).
"Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development" . Cell . 107 (7): 893–903.
doi :
10.1016/s0092-8674(01)00612-2 .
PMID
11779465 .
S2CID
9165928 .
Song, J.; Takeda, M.; Morimoto, R.I. (2001). "Hsp70-Bag1 Complex Mediates a Physiological Stress Signaling Pathway that Regulates Raf-1/Erk and Cell Growth". Nature Cell Biology . 3 (3): 276–282.
doi :
10.1038/35060068 .
PMID
11231577 .
S2CID
9081104 .
Thress, K.; Song, J.; Morimoto, R.I.; Kornbluth, S. (2001).
"Reversible Inhibition of Hsp70 Chaperone Function by Scythe and Reaper" . EMBO Journal . 20 (5): 103–1041.
doi :
10.1093/emboj/20.5.1033 .
PMC
145500 .
PMID
11230127 .
Satyal, S.; Schmidt, E.; Kitagawa, K.; Sondheimer, N.; Lindquist, S.; Morimoto, R.I. (2000).
"Polyglutamine Aggregates Alter Protein Folding Homeostasis in C. elegans" . Proc. Natl. Acad. Sci. USA . 97 (11): 5750–5755.
doi :
10.1073/pnas.100107297 .
PMC
18505 .
PMID
10811890 .
Shi, Y. D. Mosser; Morimoto, R.I. (1998).
"Molecular Chaperones as HSF1 Specific Transcriptional Repressors" . Genes & Development . 12 (5): 654–666.
doi :
10.1101/gad.12.5.654 .
PMC
316571 .
PMID
9499401 .
Morimoto, R.I. (1998).
"Regulation of the Heat Shock Transcriptional Response: Crosstalk between a Family of Heat Shock Factors, Molecular Chaperones, and Negative Regulators" . Genes & Development . 12 (24): 3788–3796.
doi :
10.1101/gad.12.24.3788 .
PMID
9869631 .
Kanei-Ishii, C. Tanikawa J. Nakai A. Morimoto R.I.; Ishii, S. (1997). "Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress". Science . 277 (5323): 246–8.
doi :
10.1126/science.277.5323.246 .
PMID
9211854 .
Freeman, B.C.; Toft, D.; Morimoto, R.I.; Chaperone Machines, Molecular (1996). "Chaperone Activities of the Cyclophilin CyP-40 and the Steroid Aporeceptor Associated Protein p23". Science . 274 (5293): 1718–1720.
doi :
10.1126/science.274.5293.1718 .
PMID
8939864 .
S2CID
333463 .
Freeman, B.C.; Morimoto, R.I. (1996).
"The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native Protein and Protein Refolding" . EMBO Journal . 15 (12): 2969–2979.
doi :
10.1002/j.1460-2075.1996.tb00660.x .
PMC
450238 .
PMID
8670798 .
Lee, B.; Chen, J.; Jurivich, D.; Angelidis, C.; Morimoto, R.I. (1995).
"Pharmacological Modulation of the Heat Shock Factor Activity by Anti-Inflammatory Drugs Protects Against Stress-Induced Cellular Damage" . Proc. Natl. Acad. Sci. USA . 92 (16): 7207–7211.
doi :
10.1073/pnas.92.16.7207 .
PMC
41308 .
PMID
7638169 .
Abravaya, K.; Myers, M.; Murphy, S.; Morimoto, R.I. (1992).
"Human Heat Shock Protein HSP70 Interacts with HSF, the Transcription Factor That Regulates Heat Shock Gene Expression" . Genes & Development . 6 (7): 1153–1164.
doi :
10.1101/gad.6.7.1153 .
PMID
1628823 .
Jurivich, D.; Sistonen, L.; Kroes, R.; Morimoto, R.I. (1992). "Effects of Sodium Salicylate on the Human Heat Shock Response". Science . 255 (5049): 1243–1245.
Bibcode :
1992Sci...255.1243J .
doi :
10.1126/science.1546322 .
PMID
1546322 .
Abravaya, K.; Phillips, B.; Morimoto, R.I. (1991).
"Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures" . Genes & Development . 5 (11): 2117–27.
doi :
10.1101/gad.5.11.2117 .
PMID
1936996 .
Sarge, K.; Zimarino, V.; Holm, K.; Wu, C.; Morimoto, R.I. (1991).
"Cloning and Characterization of Two Mouse Heat Shock Transcription Factors with Distinct Inducible and Constitutive DNA Binding Ability" . Genes & Development . 5 (10): 1902–1911.
doi :
10.1101/gad.5.10.1902 .
PMID
1717345 .
Wu, B.; Hunt, C.; Morimoto, R.I. (1985).
"The Structure and Expression of the Human Gene Encoding the Major Heat Shock Protein HSP70" . Mol. Cell. Biol . 5 (2): 330–341.
doi :
10.1128/mcb.5.2.330 .
PMC
366716 .
PMID
2858050 .
In pop culture
In a YouTube video
[6] published in 2009, members of the Morimoto lab showed C. elegans forming a smiley face on a culture plate. The video description jokes that when a post doc in the lab told them to smile, the C. elegans , lacking faces as individuals, formed the smiley face as a group, suggesting that they are intelligent, have ears, and can work in groups. In reality, the footage is playing in reverse: the C. elegans were placed into that formation on the plate by a human and then crawled away. By reversing the footage, it looks like the C. elegans spontaneously form a smiley face. The video manipulation is hinted at in the description that reminds the viewers that the YFP is brighter in the individuals' head than their tails.
References
External links
International National Academics Other