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Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase RNF216 is an
enzyme that in humans is encoded by the RNF216
gene .
[5]
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
[5]
See also
Interactions
RNF216 has been shown to
interact with
TLR9
[6] and
RIPK1 .
[7]
References
Further reading
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External links