From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Rho-related GTP-binding protein RhoQ is a
protein that in humans is encoded by the RHOQ
gene .
[5]
[6]
TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM]
[6]
In melanocytic cells RHOQ gene expression may be regulated by
MITF .
[7]
Interactions
RHOQ has been shown to
interact with
EXOC7 ,
[8]
GOPC ,
[9]
PARD6B ,
[9]
[10]
WASL ,
[11]
CDC42EP2 ,
[12]
TRIP10
[13] and
CDC42EP3 .
[12]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000119729 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000024143 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990).
"Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line" . Mol Cell Biol . 10 (4): 1793–8.
doi :
10.1128/mcb.10.4.1793 .
PMC
362288 .
PMID
2108320 .
^
a
b
"Entrez Gene: RHOQ ras homolog gene family, member Q" .
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008).
"Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76.
doi :
10.1111/j.1755-148X.2008.00505.x .
PMID
19067971 .
S2CID
24698373 .
^ Inoue M, Chang Louise, Hwang Joseph, Chiang Shian-Huey, Saltiel Alan R (April 2003).
"The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF) .
Nature . 422 (6932). England: 629–33.
Bibcode :
2003Natur.422..629I .
doi :
10.1038/nature01533 .
hdl :
2027.42/62982 .
ISSN
0028-0836 .
PMID
12687004 .
S2CID
4395760 .
^
a
b Neudauer CL, Joberty G, Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun . 280 (2). United States: 541–7.
doi :
10.1006/bbrc.2000.4160 .
ISSN
0006-291X .
PMID
11162552 .
^ Joberty G, Petersen C, Gao L, Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol . 2 (8). ENGLAND: 531–9.
doi :
10.1038/35019573 .
ISSN
1465-7392 .
PMID
10934474 .
S2CID
27139234 .
^ Abe T, Kato Masayoshi, Miki Hiroaki, Takenawa Tadaomi, Endo Takeshi (January 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell Sci . 116 (Pt 1). England: 155–68.
doi :
10.1242/jcs.00208 .
ISSN
0021-9533 .
PMID
12456725 .
S2CID
26953137 .
^
a
b Joberty G, Perlungher R R, Macara I G (October 1999).
"The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins" . Mol. Cell. Biol . 19 (10). UNITED STATES: 6585–97.
doi :
10.1128/MCB.19.10.6585 .
ISSN
0270-7306 .
PMC
84628 .
PMID
10490598 .
^ Chang L, Adams Rachael D, Saltiel Alan R (October 2002).
"The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes" .
Proc. Natl. Acad. Sci. U.S.A. 99 (20). United States: 12835–40.
Bibcode :
2002PNAS...9912835C .
doi :
10.1073/pnas.202495599 .
ISSN
0027-8424 .
PMC
130546 .
PMID
12242347 .
Further reading
Murphy GA, Solski PA, Jillian SA, et al. (1999). "Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth". Oncogene . 18 (26): 3831–45.
doi :
10.1038/sj.onc.1202758 .
PMID
10445846 .
S2CID
13589258 .
Joberty G, Perlungher RR, Macara IG (2000).
"The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins" . Mol. Cell. Biol . 19 (10): 6585–97.
doi :
10.1128/MCB.19.10.6585 .
PMC
84628 .
PMID
10490598 .
Joberty G, Petersen C, Gao L, Macara IG (2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol . 2 (8): 531–9.
doi :
10.1038/35019573 .
PMID
10934474 .
S2CID
27139234 .
Vignal E, De Toledo M, Comunale F, et al. (2000).
"Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42" . J. Biol. Chem . 275 (46): 36457–64.
doi :
10.1074/jbc.M003487200 .
PMID
10967094 .
Michaelson D, Silletti J, Murphy G, et al. (2001).
"Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding" . J. Cell Biol . 152 (1): 111–26.
doi :
10.1083/jcb.152.1.111 .
PMC
2193662 .
PMID
11149925 .
Neudauer CL, Joberty G, Macara IG (2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun . 280 (2): 541–7.
doi :
10.1006/bbrc.2000.4160 .
PMID
11162552 .
Chiang SH, Hou JC, Hwang J, et al. (2002).
"Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport" . J. Biol. Chem . 277 (15): 13067–73.
doi :
10.1074/jbc.M109471200 .
PMID
11821390 .
Kanzaki M, Watson RT, Hou JC, et al. (2003).
"Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes" . Mol. Biol. Cell . 13 (7): 2334–46.
doi :
10.1091/mbc.01-10-0490 .
PMC
117317 .
PMID
12134073 .
Chang L, Adams RD, Saltiel AR (2002).
"The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes" . Proc. Natl. Acad. Sci. U.S.A . 99 (20): 12835–40.
Bibcode :
2002PNAS...9912835C .
doi :
10.1073/pnas.202495599 .
PMC
130546 .
PMID
12242347 .
Abe T, Kato M, Miki H, et al. (2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell Sci . 116 (Pt 1): 155–68.
doi :
10.1242/jcs.00208 .
PMID
12456725 .
S2CID
26953137 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Heilig R, Eckenberg R, Petit JL, et al. (2003).
"The DNA sequence and analysis of human chromosome 14" . Nature . 421 (6923): 601–7.
Bibcode :
2003Natur.421..601H .
doi :
10.1038/nature01348 .
PMID
12508121 .
Watson RT, Furukawa M, Chiang SH, et al. (2003).
"The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes" . Mol. Cell. Biol . 23 (3): 961–74.
doi :
10.1128/MCB.23.3.961-974.2003 .
PMC
140699 .
PMID
12529401 .
Inoue M, Chang L, Hwang J, et al. (2003).
"The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin" (PDF) . Nature . 422 (6932): 629–33.
Bibcode :
2003Natur.422..629I .
doi :
10.1038/nature01533 .
hdl :
2027.42/62982 .
PMID
12687004 .
S2CID
4395760 .
Chunqiu Hou J, Pessin JE (2004).
"Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin" . Mol. Biol. Cell . 14 (9): 3578–91.
doi :
10.1091/mbc.E03-01-0012 .
PMC
196551 .
PMID
12972548 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ng Y, Tan I, Lim L, Leung T (2004).
"Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding" . J. Biol. Chem . 279 (33): 34156–64.
doi :
10.1074/jbc.M405252200 .
PMID
15194684 .
Ruusala A, Aspenström P (2004).
"Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology" . FEBS Lett . 572 (1–3): 159–66.
doi :
10.1016/j.febslet.2004.06.095 .
PMID
15304341 .
S2CID
9107914 .
Nalbant P, Hodgson L, Kraynov V, et al. (2004). "Activation of endogenous Cdc42 visualized in living cells". Science . 305 (5690): 1615–9.
Bibcode :
2004Sci...305.1615N .
doi :
10.1126/science.1100367 .
PMID
15361624 .
S2CID
42166147 .