From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Regulator of G-protein signaling 7 is a
protein that in humans is encoded by the RGS7
gene .
[5]
[6]
RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled
GPCR . RGS7 is a
GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.
[7]
Interactions
RGS7 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000182901 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026527 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Koelle MR, Horvitz HR (Feb 1996).
"EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins" . Cell . 84 (1): 115–25.
doi :
10.1016/S0092-8674(00)80998-8 .
PMID
8548815 .
S2CID
7815240 .
^
"Entrez Gene: RGS7 regulator of G-protein signalling 7" .
^ Anderson GR, Posokhova E, Martemyanov KA (July 2009).
"The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling" .
Cell Biochemistry and Biophysics . 54 (1–3): 33–46.
doi :
10.1007/s12013-009-9052-9 .
PMC
2827338 .
PMID
19521673 .
^ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999).
"Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins" . Proc. Natl. Acad. Sci. U.S.A . 96 (5): 2503–7.
Bibcode :
1999PNAS...96.2503L .
doi :
10.1073/pnas.96.5.2503 .
PMC
26814 .
PMID
10051672 .
^ Posner BA, Gilman AG, Harris BA (Oct 1999).
"Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways" . J. Biol. Chem . 274 (43): 31087–93.
doi :
10.1074/jbc.274.43.31087 .
PMID
10521509 .
^
a
b Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012).
"GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes" . J. Cell Biol . 197 (6): 711–9.
doi :
10.1083/jcb.201202123 .
PMC
3373406 .
PMID
22689652 .
^ Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999).
"Interaction between RGS7 and polycystin" . Proc. Natl. Acad. Sci. U.S.A . 96 (11): 6371–6.
Bibcode :
1999PNAS...96.6371K .
doi :
10.1073/pnas.96.11.6371 .
PMC
26888 .
PMID
10339594 .
^ Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun . 303 (2): 594–9.
doi :
10.1016/S0006-291X(03)00400-5 .
PMID
12659861 .
Further reading
Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998).
"RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells" . J. Neurochem . 70 (5): 1964–72.
doi :
10.1046/j.1471-4159.1998.70051964.x .
PMID
9572280 .
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999).
"Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins" . Proc. Natl. Acad. Sci. U.S.A . 96 (5): 2503–7.
Bibcode :
1999PNAS...96.2503L .
doi :
10.1073/pnas.96.5.2503 .
PMC
26814 .
PMID
10051672 .
Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999).
"RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents" . J. Biol. Chem . 274 (14): 9899–904.
doi :
10.1074/jbc.274.14.9899 .
PMID
10092682 .
Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (1999).
"Interaction between RGS7 and polycystin" . Proc. Natl. Acad. Sci. U.S.A . 96 (11): 6371–6.
Bibcode :
1999PNAS...96.6371K .
doi :
10.1073/pnas.96.11.6371 .
PMC
26888 .
PMID
10339594 .
Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999).
"Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11" . Proc. Natl. Acad. Sci. U.S.A . 96 (11): 6489–94.
Bibcode :
1999PNAS...96.6489S .
doi :
10.1073/pnas.96.11.6489 .
PMC
26909 .
PMID
10339615 .
Posner BA, Gilman AG, Harris BA (1999).
"Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways" . J. Biol. Chem . 274 (43): 31087–93.
doi :
10.1074/jbc.274.43.31087 .
PMID
10521509 .
Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G (2000).
"14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity" . J. Biol. Chem . 275 (36): 28167–72.
doi :
10.1074/jbc.M002905200 .
PMID
10862767 .
Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR (2000).
"RGS7 is palmitoylated and exists as biochemically distinct forms" . J. Neurochem . 75 (5): 2103–12.
doi :
10.1046/j.1471-4159.2000.0752103.x .
PMID
11032900 .
S2CID
20156736 .
Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF (2001).
"Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain" . J. Biol. Chem . 276 (13): 10284–9.
doi :
10.1074/jbc.M009247200 .
PMID
11152459 .
Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E (2002).
"Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha" . J. Biol. Chem . 277 (36): 32954–62.
doi :
10.1074/jbc.M200859200 .
PMID
12077120 .
Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun . 303 (2): 594–9.
doi :
10.1016/S0006-291X(03)00400-5 .
PMID
12659861 .
Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ (2003).
"G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction" . J. Biol. Chem . 278 (23): 21307–13.
doi :
10.1074/jbc.M212884200 .
PMID
12670932 .
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (2004).
"The human plasma proteome: a nonredundant list developed by combination of four separate sources" (PDF) . Mol. Cell. Proteomics . 3 (4): 311–26.
doi :
10.1074/mcp.M300127-MCP200 .
PMID
14718574 .
S2CID
7710900 .
Takida S, Fischer CC, Wedegaertner PB (2005).
"Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo" . Mol. Pharmacol . 67 (1): 132–9.
doi :
10.1124/mol.104.003418 .
PMC
1405920 .
PMID
15496508 .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006).
"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ (2006).
"R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism" . J. Biol. Chem . 281 (38): 28222–31.
doi :
10.1074/jbc.M604428200 .
PMID
16867977 .