Regulator of G-protein signaling 11 is a
protein that in humans is encoded by the RGS11gene.[5][6]
The protein encoded by this gene belongs to the RGS (
regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing
G proteins. This protein inhibits signal transduction by increasing the
GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct
isoforms have been identified.[6]
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85.
doi:
10.1006/geno.2002.6693.
PMID11829488.
S2CID16065132.