From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DNA repair protein RAD51 homolog 4 is a
protein that in humans is encoded by the RAD51L3
gene .
[5]
[6]
Function
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.
[6]
Interactions
RAD51L3 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000185379 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000018841 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Pittman DL, Weinberg LR, Schimenti JC (June 1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene". Genomics . 49 (1): 103–11.
doi :
10.1006/geno.1998.5226 .
PMID
9570954 .
^
a
b
"Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae)" .
^
a
b Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (November 2003).
"Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)" . J. Biol. Chem . 278 (48): 48357–66.
doi :
10.1074/jbc.M308838200 .
hdl :
10026.1/10297 .
PMID
12975363 .
^
a
b Liu N, Schild D, Thelen MP, Thompson LH (February 2002).
"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells" . Nucleic Acids Res . 30 (4): 1009–15.
doi :
10.1093/nar/30.4.1009 .
PMC
100342 .
PMID
11842113 .
^ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002).
"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51" . J. Biol. Chem . 277 (10): 8406–11.
doi :
10.1074/jbc.M108306200 .
PMID
11744692 .
^ Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (June 2000).
"Evidence for simultaneous protein interactions between human Rad51 paralogs" . J. Biol. Chem . 275 (22): 16443–9.
doi :
10.1074/jbc.M001473200 .
PMID
10749867 .
^ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004).
"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways" . Hum. Mol. Genet . 13 (12): 1241–8.
doi :
10.1093/hmg/ddh135 .
PMID
15115758 .
Further reading
Cartwright R, Dunn AM, Simpson PJ, Tambini CE, Thacker J (1998).
"Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family" . Nucleic Acids Res . 26 (7): 1653–9.
doi :
10.1093/nar/26.7.1653 .
PMC
147465 .
PMID
9512535 .
Kawabata M, Saeki K (1999). "Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the rec A/RAD51 gene family". Biochem. Biophys. Res. Commun . 257 (1): 156–62.
doi :
10.1006/bbrc.1999.0413 .
PMID
10092526 .
Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (2000).
"Evidence for simultaneous protein interactions between human Rad51 paralogs" . J. Biol. Chem . 275 (22): 16443–9.
doi :
10.1074/jbc.M001473200 .
PMID
10749867 .
Braybrooke JP, Spink KG, Thacker J, Hickson ID (2000).
"The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2" . J. Biol. Chem . 275 (37): 29100–6.
doi :
10.1074/jbc.M002075200 .
PMID
10871607 .
Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (2002).
"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51" . J. Biol. Chem . 277 (10): 8406–11.
doi :
10.1074/jbc.M108306200 .
PMID
11744692 .
Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC (2001).
"Identification and purification of two distinct complexes containing the five RAD51 paralogs" . Genes Dev . 15 (24): 3296–307.
doi :
10.1101/gad.947001 .
PMC
312846 .
PMID
11751635 .
Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P (2001).
"Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange" . Genes Dev . 15 (24): 3308–18.
doi :
10.1101/gad.935501 .
PMC
312844 .
PMID
11751636 .
Kurumizaka H, Ikawa S, Nakada M, Enomoto R, Kagawa W, Kinebuchi T, Yamazoe M, Yokoyama S, Shibata T (2002).
"Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex" . J. Biol. Chem . 277 (16): 14315–20.
doi :
10.1074/jbc.M105719200 .
PMID
11834724 .
Wiese C, Collins DW, Albala JS, Thompson LH, Kronenberg A, Schild D (2002).
"Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells" . Nucleic Acids Res . 30 (4): 1001–8.
doi :
10.1093/nar/30.4.1001 .
PMC
100332 .
PMID
11842112 .
Liu N, Schild D, Thelen MP, Thompson LH (2002).
"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells" . Nucleic Acids Res . 30 (4): 1009–15.
doi :
10.1093/nar/30.4.1009 .
PMC
100342 .
PMID
11842113 .
Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002).
"Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1" . Oncogene . 21 (32): 5002–5.
doi :
10.1038/sj.onc.1205656 .
PMID
12118380 .
Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (2003).
"Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)" . J. Biol. Chem . 278 (48): 48357–66.
doi :
10.1074/jbc.M308838200 .
hdl :
10026.1/10297 .
PMID
12975363 .
Hillman RT, Green RE, Brenner SE (2004).
"An unappreciated role for RNA surveillance" . Genome Biol . 5 (2): R8.
doi :
10.1186/gb-2004-5-2-r8 .
PMC
395752 .
PMID
14759258 .
Tarsounas M, Davies AA, West SC (2004).
"RAD51 localization and activation following DNA damage" . Philos. Trans. R. Soc. Lond. B Biol. Sci . 359 (1441): 87–93.
doi :
10.1098/rstb.2003.1368 .
PMC
1693300 .
PMID
15065660 .
Tarsounas M, Muñoz P, Claas A, Smiraldo PG, Pittman DL, Blasco MA, West SC (2004).
"Telomere maintenance requires the RAD51D recombination/repair protein" . Cell . 117 (3): 337–47.
doi :
10.1016/S0092-8674(04)00337-X .
PMID
15109494 .
S2CID
16478454 .
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (2004).
"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways" . Hum. Mol. Genet . 13 (12): 1241–8.
doi :
10.1093/hmg/ddh135 .
PMID
15115758 .
Rodríguez-López R, Osorio A, Ribas G, Pollán M, Sánchez-Pulido L, de la Hoya M, Ruibal A, Zamora P, Arias JI, Salazar R, Vega A, Martínez JI, Esteban-Cardeñosa E, Alonso C, Letón R, Urioste Azcorra M, Miner C, Armengod ME, Carracedo A, González-Sarmiento R, Caldés T, Díez O, Benítez J (2004).
"The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations" . Int. J. Cancer . 110 (6): 845–9.
doi :
10.1002/ijc.20169 .
PMID
15170666 .
S2CID
6309119 .
Loveday C, Turnbull C, Ramsay E, Hughes D, Ruark E, Frankum JR, Bowden G, Kalmyrzaev B, Warren-Perry M, Snape K, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Eccles D, Evans DG, Renwick A, Seal S, Lord CJ, Ashworth A, Reis-Filho JS, Antoniou AC, Rahman N (2011-08-07).
"Germline mutations in RAD51D confer susceptibility to ovarian cancer" . Nat. Genet . 43 (9): 879–82.
doi :
10.1038/ng.893 .
PMC
4845885 .
PMID
21822267 .