From Wikipedia, the free encyclopedia
Chemical compound
Proscillaridin
Other names 14β-Hydroxy-3β-[α-L -rhamnopyranosyl)oxy]bufa-4,20,22-trienolide
AHFS /
Drugs.com
International Drug Names
ATC code
5-[(3S ,8R ,9S ,10R ,13R ,14S ,17R )-14-Hydroxy- 10,13-dimethyl-3-((2R ,3R ,4R ,5R ,6R )-3,4,5-trihydroxy- 6-methyltetrahydro-2H -pyran-2-yloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H -cyclopenta[a ]phenanthren-17-yl]-2H -pyran-2-one
CAS Number
PubChem
CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (
EPA )
ECHA InfoCard
100.006.702
Formula C 30 H 42 O 8
Molar mass 530.658 g·mol−1 3D model (
JSmol )
O=C\1O\C=C(/C=C/1)[C@H]2CC[C@@]6(O)[C@]2(C)CC[C@H]5[C@H]6CC/C4=C/[C@@H](O[C@@H]3O[C@H]([C@H](O)[C@@H](O)[C@H]3O)C)CC[C@@]45C
InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1
Y Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N
Y
N Y
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Proscillaridin is a
cardiac glycoside , a kind of drug that can be used in the treatment of
congestive heart failure and
cardiac arrhythmia (irregular heartbeat). It is of the
bufanolide type and can be obtained from plants of the genus
Scilla and in
Drimia maritima (Scilla maritima ).
[1]
The
aglycone of proscillaridin is
scillarenin .
References
^ Kedra M, Kedrowa S (May 1968). "[Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima]". Polski Tygodnik Lekarski . 23 (19): 714–6.
PMID
4876207 .