Propionylation is a post-translational modification of proteins, in which a propionyl-group is added to a lysine amino acid of a protein. Propionylation participates in crucial biological processes, including metabolic processes and cellular stress response. [1]
Lysine propionylation was first identified on histone proteins, [2] and since has also been identified on other proteins. [3] Histone propionylation is a mark of active chromatin. [4] The substrate for protein propionylation is propionyl-CoA. Propionyl-CoA in the cell is metabolised by the enzyme propionyl-CoA carboxylase. Accumulation of propionyl-CoA leads to increased protein propionylation. [5]
In patients with propionic acidemia, a rare autosomal recessive metabolic disorder, propionyl-CoA levels elevated and increased propionylation, [6] which might contribute to the pathology in these patients. [5]
References
- ^ Shui, Ke; Wang, Chenwei; Zhang, Xuedi; Ma, Shanshan; Li, Qinyu; Ning, Wanshan; Zhang, Weizhi; Chen, Miaomiao; Peng, Di; Hu, Hui; Fang, Zheng; Guo, Anyuan; Gao, Guanjun; Ye, Mingliang; Zhang, Luoying (2023-05-17). "Small-sample learning reveals propionylation in determining global protein homeostasis". Nature Communications. 14 (1): 2813. Bibcode: 2023NatCo..14.2813S. doi: 10.1038/s41467-023-38414-8. ISSN 2041-1723. PMC 10192394. PMID 37198164.
- ^ Chen, Y; Sprung, R; Tang, Y; Ball, H; Sangras, B; Kim, SC; Falck, JR; Peng, J; Gu, W; Zhao, Y (May 2007). "Lysine propionylation and butyrylation are novel post-translational modifications in histones". Molecular & Cellular Proteomics. 6 (5): 812–9. doi: 10.1074/mcp.M700021-MCP200. PMC 2911958. PMID 17267393.
- ^ Cheng, Z; Tang, Y; Chen, Y; Kim, S; Liu, H; Li, SS; Gu, W; Zhao, Y (January 2009). "Molecular characterization of propionyllysines in non-histone proteins". Molecular & Cellular Proteomics. 8 (1): 45–52. doi: 10.1074/mcp.M800224-MCP200. PMC 2621001. PMID 18753126.
- ^ Kebede, Adam F.; Nieborak, Anna; Shahidian, Lara Zorro; Le Gras, Stephanie; Richter, Florian; Gómez, Diana Aguilar; Baltissen, Marijke P.; Meszaros, Gergo; Magliarelli, Helena de Fatima; Taudt, Aaron; Margueron, Raphael (December 2017). "Histone propionylation is a mark of active chromatin". Nature Structural & Molecular Biology. 24 (12): 1048–1056. doi: 10.1038/nsmb.3490. hdl: 2066/207705. ISSN 1545-9985. PMID 29058708. S2CID 9788234.
- ^ a b Lagerwaard, Bart; Pougovkina, Olga; Bekebrede, Anna F.; Brinke, Heleen; Wanders, Ronald J.A.; Nieuwenhuizen, Arie G.; Keijer, Jaap; Boer, Vincent C. J. (2020-08-17). "Increased protein propionylation contributes to mitochondrial dysfunction in liver cells and fibroblasts, but not in myotubes". Journal of Inherited Metabolic Disease. 44 (2): 438–449. doi: 10.1002/jimd.12296. ISSN 0141-8955. PMC 8049071. PMID 32740932.
- ^ Pougovkina, Olga; Te Brinke, Heleen; Wanders, Ronald J. A.; Houten, Sander M.; de Boer, Vincent C. J. (September 2014). "Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism". Journal of Inherited Metabolic Disease. 37 (5): 709–714. doi: 10.1007/s10545-014-9684-9. ISSN 1573-2665. PMID 24531926. S2CID 26627794.