Propazepine is a
tricyclic antidepressant (TCA).[1] Propazepine is sometimes confused with
imipramine, which has the central ring nitrogen in a different location.[1] Prazepine is the
International nonproprietary name of this compound.[2] Prazepine is also reported to be one of the many synonyms of
imipramine.[3] Propazepine can be synthesized chemically.[4][5] Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests;[citation needed] therefore, there is little information about it.
References
^
abBenešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia. 3 (6): 423–431.
doi:
10.1007/BF00411159.
PMID13967414.
S2CID1109255.
^Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry. 8: 74–80.
doi:
10.1021/jm00325a016.
PMID14287270.
^Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" [Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins]. Collection of Czechoslovak Chemical Communications (in Czech). 30 (2): 445–462.
doi:
10.1135/cccc19650445.
Further reading
Vojtechovsky, M; Safratova, V; Soukupova, B (1970). "The influence of propazepine on learning and memory in healthy volunteers and in patients with slight chronic brain syndrome". Activitas Nervosa Superior (in Czech). 12 (3): 251–2.
ISSN0001-7604.
PMID5457443.
Rysánek, K; Vítek, V; Svehla, C (1965). "Serotonin level in human and animal thrombocytes after imipramine and propazepine administration". Activitas Nervosa Superior (in Czech). 7 (3): 261–2.
ISSN0001-7604.
PMID5882104.
Souskova, M; Votava, Z; Roth, Z (1964). "Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation Reaction and Conditioned Defense Reaction in Rats". Activitas Nervosa Superior (in Czech). 6: 258–67.
ISSN0001-7604.
PMID14179381.
Vinarova, M; Nahunek, K; Vencovsky, E; Bast Ecky, J; Hadlik, J (1962). "Blind comparison of clinical effects of Imipramine and Propazepine". Activitas Nervosa Superior (in Czech). 4: 227–8.
ISSN0001-7604.
PMID13926058.
Souskova, M; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by a conditioned reflex method in rats". Activitas Nervosa Superior (in Czech). 4: 218–9.
ISSN0001-7604.
PMID13915453.
Benesova, O; Bohdanecky, Z; Votava, Z (1962). "Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes". Activitas Nervosa Superior (in Czech). 4: 215–6.
ISSN0001-7604.
PMID13867184.
Metysova, J; Votava, Z (1961). "Comparison of pharmacological properties of propazepine and imipramine". Activitas Nervosa Superior (in Czech). 3: 227.
ISSN0001-7604.
PMID14473038.