From Wikipedia, the free encyclopedia
Variability in the size and shape of a cell or nucleus
A
micrograph showing cells with marked nuclear shape and size variation, a component of nuclear pleomorphism .
Pleomorphism is a term used in
histology and
cytopathology to describe variability in the size, shape and
staining of
cells and/or their
nuclei . Several key determinants of cell and nuclear size, like
ploidy and the regulation of cellular
metabolism , are commonly disrupted in
tumors .
[1] Therefore, cellular and nuclear pleomorphism is one of the earliest hallmarks of
cancer progression and a feature characteristic of
malignant neoplasms and dysplasia.
[2]
[3] Certain
benign cell types may also exhibit pleomorphism, e.g.
neuroendocrine cells ,
Arias-Stella reaction .
A rare type of
rhabdomyosarcoma that is found in adults is known as pleomorphic rhabdomyosarcoma .
[4]
Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear. In
epithelial
tissue , pleomorphism in cellular size can induce packing defects and disperse aberrant cells.
[5] But the consequence of atypical cell and nuclear morphology in other tissues is unknown.
See also
References
^ Schmoller, Kurt M.; Skotheim, Jan M. (December 2015).
"The Biosynthetic Basis of Cell Size Control" . Trends Cell Biol . 25 (12): 793–802.
doi :
10.1016/j.tcb.2015.10.006 .
PMC
6773270 .
PMID
26573465 .
^ Travis, W.D.; Brambilla, B.; Burke, A.P; Marx, A.; Nicholson, A.G. (2015).
WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart . Lyon: International Agency for Research on Cancer.
ISBN
978-92-832-2436-5 . Archived from
the original on March 21, 2015.
^ El-Naggar, A.K.; Chan, J.C.K.; Grandis, J.R.; Takata, T.; Slootweg, P.J. (23 January 2017).
WHO Classification of Head and Neck Tumours . Lyon: International Agency for Research on Cancer.
ISBN
978-92-832-2438-9 . Archived from
the original on 2019-10-31. Retrieved 2019-10-31 .
^ Okazaki, Mitsuyoshi; Tajima, Hidehiro; Ohbatake, Yoshinao (21 April 2020).
"Pleomorphic rhabdomyosarcoma of the liver in an adult: a rare case report" . BMC Surgery . 20 (1): 81.
doi :
10.1186/s12893-020-00742-7 .
PMC
7171846 .
PMID
32316960 .
^ Ramanathan, Subramanian P.; Krajnc, Matej; Gibson, Matthew C. (October 2019).
"Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia" . Developmental Cell . 51 (1): 49–61.e4.
doi :
10.1016/j.devcel.2019.08.005 .
PMC
6903429 .
PMID
31495693 .