| Combination of | |
|---|---|
| Piperaquine | Antimalarial |
| Dihydroartemisinin | Antimalarial |
| Clinical data | |
| Trade names | DuoCotecxin, Artekin, Eurartesim, others |
| Other names | Dihydroartemisinin/piperaquine phosphate |
|
Routes of administration | By mouth |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | |
Piperaquine/dihydroartemisinin (DHA/PPQ), sold under the brand name Eurartesim among others, is a fixed dose combination medication used in the treatment of malaria. [2] It is a combination of piperaquine and dihydroartemisinin. [2] Specifically it is used for malaria of the P. falciparum and P. vivax types. [3] [4] It is taken by mouth. [3]
Side effects are uncommon. [4] Concerns include the possibility of QT prolongation. [4] Versions are available for use in children. [3] Use in early pregnancy is not recommended. [4] The two medications work by different mechanisms. [4]
Piperaquine/dihydroartemisinin was approved for medical use in Europe in 2011. [3] The combination is on the World Health Organization's List of Essential Medicines. [2] [5] It is commercially available in Africa and Asia. [3] It has been used to treat more than 4.5 million people as of 2017. [3]
Pharmacology
Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs.
Piperaquine is an antimalarial drug, a bisquinoline first made in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. The combination dihydroartemisinin-piperaquine is an effective antimalarial that is used widely around the world. In South-East Asia, where resistance has emerged towards both artemisinin and piperaquine, the combination is being trialed with a third drug, namely mefloquine. [6]
Piperaquine is characterized by slow absorption and a long biological half-life, making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.
Society and culture
This product is available in the market of several countries:
- Artekin (Holleykin)
- Eurartesim (Alfasigma; by Good Manufacturing Practices)
- Diphos (Genix Pharma)
- Timequin (SAMI Pharma )
- Duocotecxin (Holley Pharm)
- Malacur (Elder Pharmaceuticals for SALVAT Laboratories)
- Ridmal (Ajanta Pharma Limited)
References
- ^ "Eurartesim 320 mg/40 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 10 April 2017. Archived from the original on 13 July 2020. Retrieved 2 May 2020.
- ^ a b c World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl: 10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ a b c d e f "Eurartesim EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 3 May 2020.
- ^ a b c d e "Dihydroartemisinin/Piperaquine Application for Inclusion in the 17th WHO Model List of Essential Medicines" (PDF). WHO. November 2010. Retrieved 29 June 2017.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl: 10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "TRAC II - Mahidol Oxford Tropical Medicine Research Unit". www.tropmedres.ac. Archived from the original on 28 July 2017. Retrieved 28 July 2017.
External links
- "Dihydroartemisinin mixture with piperaquine". Drug Information Portal. U.S. National Library of Medicine.
- "Dihydroartemisinin mixture with piperaquine tetraphosphate". Drug Information Portal. U.S. National Library of Medicine.
