A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes). [1]
Biological function
The phosphorylation of proteins is a major regulatory mechanism in cells. [2] [3]
Clinical significance
Phosphoproteins have been proposed as biomarkers for breast cancer. [4] [2]
See also
References
- ^ Keyword - Phosphoprotein
- ^ a b Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
- ^ Cozzone AJ (1988). "Protein phosphorylation in prokaryotes". Annu. Rev. Microbiol. 42: 97–125. doi: 10.1146/annurev.mi.42.100188.000525. PMID 2849375.
- ^ Liquid Biopsy Could Get Boost from Phosphoproteins. 2017
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