From Wikipedia, the free encyclopedia
Phenethyl isothiocyanate
Names
Preferred IUPAC name
(2-Isothiocyanatoethyl)benzene
Other names
Phenylethyl isothiocyanate; Phenethyl mustard oil
Identifiers
Abbreviations
PEITC
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
100.017.142
UNII
InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
Y Key: IZJDOKYDEWTZSO-UHFFFAOYSA-N
Y InChI=1/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2
Key: IZJDOKYDEWTZSO-UHFFFAOYAB
Properties
C 9 H 9 N S
Molar mass
163.24 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Phenethyl isothiocyanate (PEITC ) is a naturally occurring
isothiocyanate whose precursor,
gluconasturtiin is found in some
cruciferous vegetables ,
[1] especially
watercress .
PEITC has been studied for its potential for
chemoprevention of cancers,
[2]
[3] such as prostate cancer.
[4]
In terms of
biosynthesis , PEITC is produced from
gluconasturtiin by the action of the enzyme
myrosinase .
References
^
"Dictionary of Cancer Terms: PEITC" .
National Cancer Institute .
^ Cheung, KL; Kong, AN (2010).
"Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention" . The AAPS Journal . 12 (1): 87–97.
doi :
10.1208/s12248-009-9162-8 .
PMC
2811646 .
PMID
20013083 .
^ Kwon, Ki Han; Xu, Changjiang; Keum, Young-Sam; Khor, Tin Oo; Kim, Jung-Hwan; Huang, Mou-Tuan; Reddy, Bandaru S.; Li, Wenge; Kong, Ah-Ng Tony (2007). "Natural dietary phytochemicals: a promising future for cancer prevention and treatment of earlier lesion". Cancer: Disease Progression and Chemoprevention : 109–126.
^ Wang, LG; Chiao, JW (2010).
"Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review)" .
International Journal of Oncology . 37 (3): 533–9.
doi :
10.3892/ijo_00000702 .
PMID
20664922 .