From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an
enzyme that in humans is encoded by the PPP2R3A
gene .
[5]
[6]
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
[6]
Interactions
PPP2R3A has been shown to
interact with
CDC6
[7] and
PPP2R4 .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000073711 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000043154 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hendrix P, Mayer-Jackel RE, Cron P, Goris J, Hofsteenge J, Merlevede W, Hemmings BA (Aug 1993).
"Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing" . J Biol Chem . 268 (20): 15267–76.
doi :
10.1016/S0021-9258(18)82465-6 .
PMID
8392071 .
^
a
b
"Entrez Gene: PPP2R3A protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha" .
^
a
b Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (Jun 2008).
"Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit" . J. Biol. Chem . 283 (23). United States: 16104–14.
doi :
10.1074/jbc.M710313200 .
ISSN
0021-9258 .
PMC
2414307 .
PMID
18397887 .
Further reading
Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol . 60 (8): 1225–35.
doi :
10.1016/S0006-2952(00)00424-X .
PMID
11007961 .
Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res . 3 (1): 43–51.
doi :
10.2174/1570162052772988 .
PMID
15638722 .
Le Rouzic E, Benichou S (2006).
"The Vpr protein from HIV-1: distinct roles along the viral life cycle" . Retrovirology . 2 : 11.
doi :
10.1186/1742-4690-2-11 .
PMC
554975 .
PMID
15725353 .
Zhao RY, Elder RT (2005).
"Viral infections and cell cycle G2/M regulation" . Cell Res . 15 (3): 143–9.
doi :
10.1038/sj.cr.7290279 .
PMID
15780175 .
Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res . 121 (4): 270–86.
PMID
15817944 .
Mayer RE, Hendrix P, Cron P, et al. (1991). "Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform". Biochemistry . 30 (15): 3589–97.
doi :
10.1021/bi00229a001 .
PMID
1849734 .
Tung HY, De Rocquigny H, Zhao LJ, et al. (1997).
"Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr" . FEBS Lett . 401 (2–3): 197–201.
doi :
10.1016/S0014-5793(96)01470-6 .
PMID
9013886 .
S2CID
23293768 .
Ruediger R, Brewis N, Ohst K, Walter G (1998).
"Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production" . Virology . 238 (2): 432–43.
doi :
10.1006/viro.1997.8873 .
PMID
9400615 .
Ruediger R, Fields K, Walter G (1999).
"Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens" . J. Virol . 73 (1): 839–42.
doi :
10.1128/JVI.73.1.839-842.1999 .
PMC
103900 .
PMID
9847399 .
Voorhoeve PM, Hijmans EM, Bernards R (1999).
"Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein" . Oncogene . 18 (2): 515–24.
doi :
10.1038/sj.onc.1202316 .
PMID
9927208 .
Takahashi M, Shibata H, Shimakawa M, et al. (1999).
"Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus" . J. Biol. Chem . 274 (24): 17267–74.
doi :
10.1074/jbc.274.24.17267 .
PMID
10358086 .
Yan Z, Fedorov SA, Mumby MC, Williams RS (2000).
"PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells" . Mol. Cell. Biol . 20 (3): 1021–9.
doi :
10.1128/MCB.20.3.1021-1029.2000 .
PMC
85219 .
PMID
10629059 .
Lubert EJ, Hong Y, Sarge KD (2001).
"Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5" . J. Biol. Chem . 276 (42): 38582–7.
doi :
10.1074/jbc.M106906200 .
PMID
11504734 .
Elder RT, Yu M, Chen M, et al. (2001).
"HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25" . Virology . 287 (2): 359–70.
doi :
10.1006/viro.2001.1007 .
PMID
11531413 .
Dintilhac A, Bernués J (2002).
"HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences" (PDF) . J. Biol. Chem . 277 (9): 7021–8.
doi :
10.1074/jbc.M108417200 .
PMID
11748221 .
S2CID
39560486 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .