From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GPI transamidase component PIG-S is an
enzyme that in humans is encoded by the PIGS
gene .
[5]
This gene encodes a protein that is involved in GPI-anchor
biosynthesis .
The
glycosylphosphatidylinositol (GPI) anchor is a
glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI
transamidase . GPI transamidase mediates GPI anchoring in the
endoplasmic reticulum , by catalyzing the transfer of fully assembled GPI units to proteins.
[5]
References
Further reading
Ohishi K, Inoue N, Kinoshita T (2001).
"PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8" . EMBO J . 20 (15): 4088–98.
doi :
10.1093/emboj/20.15.4088 .
PMC
149153 .
PMID
11483512 .
Vainauskas S, Maeda Y, Kurniawan H, et al. (2002).
"Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex" . J. Biol. Chem . 277 (34): 30535–42.
doi :
10.1074/jbc.M205402200 .
PMID
12052837 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ohishi K, Nagamune K, Maeda Y, Kinoshita T (2003).
"Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge" . J. Biol. Chem . 278 (16): 13959–67.
doi :
10.1074/jbc.M300586200 .
PMID
12582175 .
Hong Y, Ohishi K, Kang JY, et al. (2004).
"Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins" . Mol. Biol. Cell . 14 (5): 1780–9.
doi :
10.1091/mbc.E02-12-0794 .
PMC
165076 .
PMID
12802054 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Vainauskas S, Menon AK (2005).
"Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex" . J. Biol. Chem . 280 (16): 16402–9.
doi :
10.1074/jbc.M414253200 .
PMID
15713669 .
Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26.
doi :
10.1093/dnares/12.2.117 .
PMID
16303743 .