From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Polycomb group RING finger protein 6 is a
protein that in humans is encoded by the PCGF6
gene .
[5]
[6]
The protein encoded by this gene contains a
RING finger motif, which is most closely related to those of polycomb group (PcG) proteins
RNF110/MEL-18 and
BMI1 . PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some
PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent
phosphorylation . Alternatively spliced transcript variants encoding different
isoforms have been identified.
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000156374 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000025050 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002).
"MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation" (PDF) . Genes Cells . 7 (8): 835–50.
doi :
10.1046/j.1365-2443.2002.00565.x .
hdl :
2027.42/72663 .
PMID
12167161 .
S2CID
23060582 .
^
a
b
"Entrez Gene: PCGF6 polycomb group ring finger 6" .
Further reading
Kanno M, Hasegawa M, Ishida A, et al. (1996).
"mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity" . EMBO J . 14 (22): 5672–8.
doi :
10.1002/j.1460-2075.1995.tb00254.x .
PMC
394682 .
PMID
8521824 .
Trimarchi JM, Fairchild B, Wen J, Lees JA (2001).
"The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1519–24.
doi :
10.1073/pnas.041597698 .
PMC
29289 .
PMID
11171983 .
Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development . 129 (18): 4171–83.
doi :
10.1242/dev.129.18.4171 .
PMID
12183370 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004).
"The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81.
Bibcode :
2004Natur.429..375D .
doi :
10.1038/nature02462 .
PMID
15164054 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C". Biochem. Biophys. Res. Commun . 338 (2): 855–61.
doi :
10.1016/j.bbrc.2005.10.020 .
PMID
16248985 .
Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007).
"Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein" . Cell . 128 (5): 877–87.
doi :
10.1016/j.cell.2007.02.004 .
PMID
17320162 .
S2CID
6519228 .